A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder

Satoshi Yamada, Tomohiro Nakao, Keisuke Ikari, Masumi Kuwano, Keitaro Murayama, Hirofumi Tomiyama, Suguru Hasuzawa, Osamu Togao, Hiwatashi Akio, Shigenobu Kanba

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Hoarding disorder (HD) is a disease concept newly presented in DSM-5. As far as we know, no studies have examined the structural changes relevant to hoarding by applying the diagnostic criteria of HD in DSM-5. In the present study, we aimed to find abnormalities in gray matter (GM) structures of patients with HD. Methods Seventeen patients who met the DSM-5 criteria for HD, 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups. Thereafter we investigated the correlation between the clinical data (age of onset, symptomatic severity) and GM volume. Results The HD group showed a significantly increased GM volume compared to the OCD and healthy control groups (p<0.05) in both Brodmann area (BA)10 and BA11. There was no significant difference between OCD and healthy control groups. No significant correlation between the clinical data including age of onset, symptom severity score, and GM volume was observed in HD and OCD groups. Conclusions The results might help to explain the inconsistency of previous studies. As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.

Original languageEnglish
Article numbere0200814
JournalPloS one
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

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obsessive-compulsive disorder
Obsessive-Compulsive Disorder
Magnetic resonance imaging
Brain
Scanning
scanners
Age of Onset
pathophysiology
signs and symptoms (animals and humans)
Hoarding Disorder
Gray Matter
Control Groups
brain

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder. / Yamada, Satoshi; Nakao, Tomohiro; Ikari, Keisuke; Kuwano, Masumi; Murayama, Keitaro; Tomiyama, Hirofumi; Hasuzawa, Suguru; Togao, Osamu; Akio, Hiwatashi; Kanba, Shigenobu.

In: PloS one, Vol. 13, No. 7, e0200814, 01.07.2018.

Research output: Contribution to journalArticle

Yamada, Satoshi ; Nakao, Tomohiro ; Ikari, Keisuke ; Kuwano, Masumi ; Murayama, Keitaro ; Tomiyama, Hirofumi ; Hasuzawa, Suguru ; Togao, Osamu ; Akio, Hiwatashi ; Kanba, Shigenobu. / A unique increase in prefrontal gray matter volume in hoarding disorder compared to obsessive-compulsive disorder. In: PloS one. 2018 ; Vol. 13, No. 7.
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