A variant form of septo-optic-pituitary dysplasia (SOPD) complicated with acute optic neuritis

H. Nakagaki, H. Furuya, Hiroyuki Murai, Y. Ohyagi, T. Yamada, Jun-Ichi Kira, Shozo Tobimatsu

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Abstract

We herein report a case of a variant form of septo-optic-pituitary dysplasia (SOPD). A 40-year-old man was admitted due to sudden occurrence of left blurred vision and lasting polyuria. He showed short statue of height of 144 cm and the neurological examination revealed hypesthesia of the left trigeminal nerve and temporal pallor in the left fundus oculi. Brain MR imaging demonstrated agenesis of the septum pellucidum and hypoplasia of the corpus callosum with subcortical spotty lesions, but optic nerve hypoplasia was not detected. The left eye showed a prolonged P100 latency of pattern reversal VEPs. He was diagnosed as having hypopituitarism since growth hormone-releasing factor did not stimulate growth hormone secretion and restriction of water-intake did not induce secretion of antidiuretic hormone. Thus we regarded this case as a variant form of SOPD. The mutation of HESX 1 gene, however, was not detected in the case. P100 of the left eye showed a reduction in latency four months after discharge. This case was considered to be a variant form of SOPD complicated by acute optic neuritis.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalClinical Neurology
Volume41
Issue number4-5
Publication statusPublished - Nov 17 2001

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Septo-Optic Dysplasia
Optic Neuritis
Fundus Oculi
Septum Pellucidum
Pallor
Polyuria
Growth Hormone-Releasing Hormone
Hypopituitarism
Trigeminal Nerve
Hypesthesia
Corpus Callosum
Neurologic Examination
Optic Nerve
Vasopressins
Neuroimaging
Growth Hormone
Drinking
Mutation
Genes

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

A variant form of septo-optic-pituitary dysplasia (SOPD) complicated with acute optic neuritis. / Nakagaki, H.; Furuya, H.; Murai, Hiroyuki; Ohyagi, Y.; Yamada, T.; Kira, Jun-Ichi; Tobimatsu, Shozo.

In: Clinical Neurology, Vol. 41, No. 4-5, 17.11.2001, p. 198-201.

Research output: Contribution to journalArticle

Nakagaki, H, Furuya, H, Murai, H, Ohyagi, Y, Yamada, T, Kira, J-I & Tobimatsu, S 2001, 'A variant form of septo-optic-pituitary dysplasia (SOPD) complicated with acute optic neuritis', Clinical Neurology, vol. 41, no. 4-5, pp. 198-201.
Nakagaki H, Furuya H, Murai H, Ohyagi Y, Yamada T, Kira J-I et al. A variant form of septo-optic-pituitary dysplasia (SOPD) complicated with acute optic neuritis. Clinical Neurology. 2001 Nov 17;41(4-5):198-201.
Nakagaki, H. ; Furuya, H. ; Murai, Hiroyuki ; Ohyagi, Y. ; Yamada, T. ; Kira, Jun-Ichi ; Tobimatsu, Shozo. / A variant form of septo-optic-pituitary dysplasia (SOPD) complicated with acute optic neuritis. In: Clinical Neurology. 2001 ; Vol. 41, No. 4-5. pp. 198-201.
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