TY - JOUR
T1 - Aaptamine-related alkaloid from the marine sponge aaptos aaptos
AU - Hamada, Toshiyuki
AU - Matsumoto, Yoshito
AU - Phan, Chin Soon
AU - Kamada, Takashi
AU - Onitsuka, Satoaki
AU - Okamura, Hiroaki
AU - Iwagawa, Tetsuo
AU - Arima, Naomichi
AU - Tani, Fumito
AU - Vairappan, Charles S.
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partly supported by (1) Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, (2) Cooperative Research Program of the “Network Joint Research Centre for Materials and Devices” (No. 20 171 299 and 20181302), and (3) Unlocking Biotechnology Potential of Sabah’s Natural Resources from Sabah Biodiversity Center (GL0070).
Funding Information:
We are grateful to Toshio Nishi (Institute for Material Chemistry and Engineering, Kyushu University) for his kind support. Declaration of Conflicting Interests. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partly supported by (1) Grants-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture of Japan, (2) Cooperative Research Program of the “Network Joint Research Centre for Materials and Devices” (No. 20 171 299 and 20181302), and (3) Unlocking Biotechnology Potential of Sabah’s Natural Resources from Sabah Biodiversity Center (GL0070).
Publisher Copyright:
© The Author(s) 2019.
PY - 2019
Y1 - 2019
N2 - A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.
AB - A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.
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U2 - 10.1177/1934578X19863935
DO - 10.1177/1934578X19863935
M3 - Article
AN - SCOPUS:85075466392
SN - 1934-578X
VL - 14
SP - 1
EP - 3
JO - Natural Product Communications
JF - Natural Product Communications
IS - 9
ER -
