Aaptamine-related alkaloid from the marine sponge aaptos aaptos

Toshiyuki Hamada, Yoshito Matsumoto, Chin Soon Phan, Takashi Kamada, Satoaki Onitsuka, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima, Fumito Tani, Charles S. Vairappan

Research output: Contribution to journalArticle

Abstract

A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalNatural product communications
Volume14
Issue number9
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Aaptos aaptos
Naphthyridines
Porifera
leukemia
Alkaloids
alkaloids
T-lymphocytes
chemical derivatives
Adult T Cell Leukemia Lymphoma
extracts
cells
aaptamine

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Hamada, T., Matsumoto, Y., Phan, C. S., Kamada, T., Onitsuka, S., Okamura, H., ... Vairappan, C. S. (2019). Aaptamine-related alkaloid from the marine sponge aaptos aaptos. Natural product communications, 14(9), 1-3. https://doi.org/10.1177/1934578X19863935

Aaptamine-related alkaloid from the marine sponge aaptos aaptos. / Hamada, Toshiyuki; Matsumoto, Yoshito; Phan, Chin Soon; Kamada, Takashi; Onitsuka, Satoaki; Okamura, Hiroaki; Iwagawa, Tetsuo; Arima, Naomichi; Tani, Fumito; Vairappan, Charles S.

In: Natural product communications, Vol. 14, No. 9, 01.01.2019, p. 1-3.

Research output: Contribution to journalArticle

Hamada, T, Matsumoto, Y, Phan, CS, Kamada, T, Onitsuka, S, Okamura, H, Iwagawa, T, Arima, N, Tani, F & Vairappan, CS 2019, 'Aaptamine-related alkaloid from the marine sponge aaptos aaptos', Natural product communications, vol. 14, no. 9, pp. 1-3. https://doi.org/10.1177/1934578X19863935
Hamada T, Matsumoto Y, Phan CS, Kamada T, Onitsuka S, Okamura H et al. Aaptamine-related alkaloid from the marine sponge aaptos aaptos. Natural product communications. 2019 Jan 1;14(9):1-3. https://doi.org/10.1177/1934578X19863935
Hamada, Toshiyuki ; Matsumoto, Yoshito ; Phan, Chin Soon ; Kamada, Takashi ; Onitsuka, Satoaki ; Okamura, Hiroaki ; Iwagawa, Tetsuo ; Arima, Naomichi ; Tani, Fumito ; Vairappan, Charles S. / Aaptamine-related alkaloid from the marine sponge aaptos aaptos. In: Natural product communications. 2019 ; Vol. 14, No. 9. pp. 1-3.
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