Aaptamine-related alkaloid from the marine sponge aaptos aaptos

Toshiyuki Hamada, Yoshito Matsumoto, Chin Soon Phan, Takashi Kamada, Satoaki Onitsuka, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima, Fumito Tani, Charles S. Vairappan

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalNatural product communications
Issue number9
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine


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