TY - JOUR
T1 - Aberrant expression of CHFR in malignant peripheral nerve sheath tumors
AU - Kobayashi, Chikashi
AU - Oda, Yoshinao
AU - Takahira, Tomonari
AU - Izumi, Teiyu
AU - Kawaguchi, Kenichi
AU - Yamamoto, Hidetaka
AU - Tamiya, Sadafumi
AU - Yamada, Tomomi
AU - Iwamoto, Yukihide
AU - Tsuneyoshi, Masazumi
N1 - Funding Information:
The English used in this manuscript was revised by Miss K Miller (Royal English Language Centre, Fukuoka, Japan). This work was supported in part by a Grant-in-Aid for Scientific Research from the Japan Society of the Promotion of Science (15590304), Tokyo, Japan.
PY - 2006/4
Y1 - 2006/4
N2 - Mitotic checkpoint maintains genomic integrity before mitosis. Numerous observations have suggested that mitotic abnormalities produce chromosomal instability and aneuploidy. In MPNST, complex karyotypes showing numerical and structural aberrations have been described. 'Checkpoint with forkhead-associated domain and ring finger' (CHFR) was recently identified as defining a new early mitotic checkpoint. We examined the expression of CHFR in 96 cases of MPNST by immunohistochemical and molecular methods. We found reduced (score, ≤3) expression of CHFR in 63 out of 96 (66%) cases of MPNST, and such alteration was significantly correlated with a high mitotic count, a high Ki-67-labeling index, and a poor prognosis. In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation.
AB - Mitotic checkpoint maintains genomic integrity before mitosis. Numerous observations have suggested that mitotic abnormalities produce chromosomal instability and aneuploidy. In MPNST, complex karyotypes showing numerical and structural aberrations have been described. 'Checkpoint with forkhead-associated domain and ring finger' (CHFR) was recently identified as defining a new early mitotic checkpoint. We examined the expression of CHFR in 96 cases of MPNST by immunohistochemical and molecular methods. We found reduced (score, ≤3) expression of CHFR in 63 out of 96 (66%) cases of MPNST, and such alteration was significantly correlated with a high mitotic count, a high Ki-67-labeling index, and a poor prognosis. In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation.
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U2 - 10.1038/modpathol.3800548
DO - 10.1038/modpathol.3800548
M3 - Article
C2 - 16554732
AN - SCOPUS:33645294004
SN - 0893-3952
VL - 19
SP - 524
EP - 532
JO - Modern Pathology
JF - Modern Pathology
IS - 4
ER -