Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

Nur Mohammad Monsur Hassan, Jun Ichi Hamada, Taichi Murai, Akihusa Seino, Yoko Takahashi, Mitsuhiro Tada, Xiuru Zhang, Haruhiko Kashiwazaki, Yutaka Yamazaki, Nobuo Inoue, Tetsuya Moriuchi

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalOncology Research
Volume16
Issue number5
Publication statusPublished - Dec 1 2006
Externally publishedYes

Fingerprint

Squamous Cell Carcinoma
Gene Expression
Genes
Mucous Membrane
Real-Time Polymerase Chain Reaction
Carcinogenesis
Transcription Factors
Lymph Nodes
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Hassan, N. M. M., Hamada, J. I., Murai, T., Seino, A., Takahashi, Y., Tada, M., ... Moriuchi, T. (2006). Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. Oncology Research, 16(5), 217-224.

Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. / Hassan, Nur Mohammad Monsur; Hamada, Jun Ichi; Murai, Taichi; Seino, Akihusa; Takahashi, Yoko; Tada, Mitsuhiro; Zhang, Xiuru; Kashiwazaki, Haruhiko; Yamazaki, Yutaka; Inoue, Nobuo; Moriuchi, Tetsuya.

In: Oncology Research, Vol. 16, No. 5, 01.12.2006, p. 217-224.

Research output: Contribution to journalArticle

Hassan, NMM, Hamada, JI, Murai, T, Seino, A, Takahashi, Y, Tada, M, Zhang, X, Kashiwazaki, H, Yamazaki, Y, Inoue, N & Moriuchi, T 2006, 'Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues', Oncology Research, vol. 16, no. 5, pp. 217-224.
Hassan NMM, Hamada JI, Murai T, Seino A, Takahashi Y, Tada M et al. Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. Oncology Research. 2006 Dec 1;16(5):217-224.
Hassan, Nur Mohammad Monsur ; Hamada, Jun Ichi ; Murai, Taichi ; Seino, Akihusa ; Takahashi, Yoko ; Tada, Mitsuhiro ; Zhang, Xiuru ; Kashiwazaki, Haruhiko ; Yamazaki, Yutaka ; Inoue, Nobuo ; Moriuchi, Tetsuya. / Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues. In: Oncology Research. 2006 ; Vol. 16, No. 5. pp. 217-224.
@article{1d2d1038e87c4d609671d100ad343059,
title = "Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues",
abstract = "Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.",
author = "Hassan, {Nur Mohammad Monsur} and Hamada, {Jun Ichi} and Taichi Murai and Akihusa Seino and Yoko Takahashi and Mitsuhiro Tada and Xiuru Zhang and Haruhiko Kashiwazaki and Yutaka Yamazaki and Nobuo Inoue and Tetsuya Moriuchi",
year = "2006",
month = "12",
day = "1",
language = "English",
volume = "16",
pages = "217--224",
journal = "Oncology Research",
issn = "0965-0407",
publisher = "Cognizant Communication Corporation",
number = "5",

}

TY - JOUR

T1 - Aberrant expression of HOX genes in oral dysplasia and squamous cell carcinoma tissues

AU - Hassan, Nur Mohammad Monsur

AU - Hamada, Jun Ichi

AU - Murai, Taichi

AU - Seino, Akihusa

AU - Takahashi, Yoko

AU - Tada, Mitsuhiro

AU - Zhang, Xiuru

AU - Kashiwazaki, Haruhiko

AU - Yamazaki, Yutaka

AU - Inoue, Nobuo

AU - Moriuchi, Tetsuya

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

AB - Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia, and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3, and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9, and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it. These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.

UR - http://www.scopus.com/inward/record.url?scp=33846837227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846837227&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 217

EP - 224

JO - Oncology Research

JF - Oncology Research

SN - 0965-0407

IS - 5

ER -