Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology

Shinichi Aishima, Shuji Matsuura, Takahiro Terashi, Kenichi Taguchi, Mitsuo Shimada, Yoshihiko Maehara, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Laminin gamma 2 chain is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. We report altered expression and characteristic localization of this chain in a series of 105 cases of intrahepatic cholangiocarcinomas examined immunohistochemically. All tumors were grossly classified into the following three types: intraductal growth type (n = 9), periductal infiltrating type (n = 8) and mass-forming type (n = 88). The tumors exhibited three distinct staining types: basement membrane staining, cytoplasmic staining and stromal staining. The basement membranous staining of laminin gamma 2 chain was more frequent in biliary dysplasia, intraductal growth and periductal infiltrating type than in mass-forming type. The cytoplasmic staining of carcinoma cells was observed especially at the cancer-stromal interface or at the invasive front of tumors. Stromal staining of laminin gamma 2 chain was essentially localized in the stroma around cancer cells at the invasive area, and the expression was significantly correlated with tumor aggressive factors and a poor prognosis in patients with intrahepatic cholangiocarcinoma. We conclude that laminin gamma 2 chain exhibits aberrant expression in a stepwise manner through different aggressive stages of tumor progression.

Original languageEnglish
Pages (from-to)938-945
Number of pages8
JournalModern Pathology
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 2004

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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