Aberrant interleukin-2, receptor-mediated blastoformation of peripheral blood lymphocytes in a severe major depressive episode

S. Kanba, H. Manki, F. Shintani, Y. Ohno, G. Yagi, M. Asai

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background. We examined interleukin-2 (IL-2) related immune pathways in depression to elucidate mechanisms underlying various immunological disturbances associated with depression. Methods. Subjects comprised 35 unmedicated patients with a major depressive episode without psychotic features and 36 age- and sex-matched healthy volunteers. The immune parameters examined included the numbers of B and T cells, IL-2 receptor-mediated blastoformation (IL-2R-mediated blastoformation), IL-2 production and expression of the IL-2 receptor α-subunit. Results. The patients with a severe episode showed significantly lower IL-2R-mediated blastoformation than the controls. There was a statistically significant negative correlation between IL-2R-mediated blastoformation and the severity of depression at the time of entry. Conclusion. The reduced IL-2R-mediated blastoformation may partly explain several previously reported abnormal immune functions associated with depression.

Original languageEnglish
Pages (from-to)481-484
Number of pages4
JournalPsychological Medicine
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 1 1998

All Science Journal Classification (ASJC) codes

  • Applied Psychology
  • Psychiatry and Mental health

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