Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder

Keitaro Murayama, Hirofumi Tomiyama, Sae Tsuruta, Aikana Ohono, Mingi Kang, Suguru Hasuzawa, Taro Mizobe, Kenta Kato, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although abnormality of cerebellar-cerebral functional connectivity at rest in obsessive-compulsive disorder (OCD) has been hypothesized, only a few studies have investigated the neural mechanism. To verify the findings of previous studies, a large sample of patients with OCD was studied because OCD shows possible heterogeneity. Methods: Forty-seven medication-free patients with OCD and 62 healthy controls (HCs) underwent resting-state functional magnetic imaging scans. Seed-based connectivity was examined to investigate differences in cerebellar-cerebral functional connectivity in OCD patients compared with HCs. Correlations between functional connectivity and the severity of obsessive-compulsive symptoms were analyzed. Results: In OCD, we found significantly increased functional connectivity between the right lobule VI and the left precuneus, which is a component of the default mode network (DMN), compared to HCs. However, there was no correlation between the connectivity of the right lobule VI-left precuneus and obsessive-compulsive severity. Conclusions: These findings suggest that altered functional connectivity between the cerebellum and DMN might cause changes in intrinsic large-scale brain networks related to the traits of OCD.

Original languageEnglish
Article number659616
JournalFrontiers in Psychiatry
Volume12
DOIs
Publication statusPublished - Apr 23 2021

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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