Abnormal expression of PFDN4 in colorectal cancer: A novel marker for prognosis

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Naohiro Nishida, Masayoshi Tokuoka, Hirofumi Akita, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: Prefoldin 4 (PFDN4) is a transcriptional factor that regulates the cell cycle. PFDN4 is upregulated in breast tumor and breast cancer cell lines, but its significance in colorectal cancer (CRC) is not fully understood. Methods: The present study assessed 129 patients who underwent surgery for CRC and assessed three cell lines derived from human CRC. The correlation of gene expression with clinical parameters in patients was assessed by knockdown experiments with these cell lines. Results: Patients with high PFDN4 expression had a statistically relatively better prognosis, and those with low PFDN4 expression showed poorer overall survival than those with high expression. The assessment of PFDN4 knockdown in the three cell lines demonstrated that the siRNA inhibition resulted in a statistically significant increase in cell growth and invasiveness. Conclusions: The data strongly suggest that PFDN4 expression is a prognostic factor in CRC.

Original languageEnglish
Pages (from-to)3030-3036
Number of pages7
JournalAnnals of Surgical Oncology
Volume17
Issue number11
DOIs
Publication statusPublished - Nov 2010

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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