Abnormally shaped arteries in the intestine of Children with Hirschsprung's disease: Etiological Considerations Relating to Ischemic Theory

Tomoaki Taguchi, Sachiyo Suita, Yuzo Hirata, Ryuichiro Hirose, Takaharu Yamada, Toshimitsu Toyohara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Abnormally shaped arteries were found in the intestines of 17 of 62 patients (27%) with Hirschsprung's disease. The histological characteristics of abnormal arteries included proliferation of collagen fibers and smooth muscle cells in the adventitia. The incidence of abnormal arteries in each type of aganglionosis was as follows: 25% (13 of 51) in short-segment aganglionosis; 0% (0 of 6) in long-segment aganglionosis; and 80% (4 of 5) in total-colon or extensive aganglionosis. The older the patients were at the time of resection, the higher the incidence of abnormal arteries (<1 year old, 15%; 1-3 years old, 38%; >3 years old, 75%). The abnormally shaped arteries were mostly located in the histological transitional zone. These findings suggest the following possibilities: (a) the cran-iocaudal migration of ganglion cells was interrupted by intestinal ischemia in the presence of abnormal arteries in utero; (b) an ischemic episode caused both the disappearance of neural cells and dysplasia of the artery; (c) the ganglion cells were destroyed by mild ischemia caused by the abnormal arteries; or (d) the tension caused by mechanical expansion resulted in a change in the vascular walls in the transitional zone.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalJournal of pediatric gastroenterology and nutrition
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 1994

Fingerprint

Hirschsprung Disease
Intestines
Arteries
Ganglia
Ischemia
Adventitia
Incidence
Smooth Muscle Myocytes
Cell Movement
Blood Vessels
Colon
Collagen

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Abnormally shaped arteries in the intestine of Children with Hirschsprung's disease : Etiological Considerations Relating to Ischemic Theory. / Taguchi, Tomoaki; Suita, Sachiyo; Hirata, Yuzo; Hirose, Ryuichiro; Yamada, Takaharu; Toyohara, Toshimitsu.

In: Journal of pediatric gastroenterology and nutrition, Vol. 18, No. 2, 02.1994, p. 200-204.

Research output: Contribution to journalArticle

Taguchi, Tomoaki ; Suita, Sachiyo ; Hirata, Yuzo ; Hirose, Ryuichiro ; Yamada, Takaharu ; Toyohara, Toshimitsu. / Abnormally shaped arteries in the intestine of Children with Hirschsprung's disease : Etiological Considerations Relating to Ischemic Theory. In: Journal of pediatric gastroenterology and nutrition. 1994 ; Vol. 18, No. 2. pp. 200-204.
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