Absolute configuration of 2-hydroxy-2-(1-naphthyl)propionic acid as determined by the 1H NMR anisotropy method

Akio Ichikawa, Shuntaro Hiradate, Akinori Sugio, Shunsuke Kuwahara, Masataka Watanabe, Nobuyuki Harada

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Enantiopure 2-hydroxy-2-(1-naphthyl)propionic acid (+)-2 was prepared by the stereoselective Grignard reaction of 1-naphthylmagnesium bromide with (1R,3R,4S)-menthyl pyruvate 3 or (1R,3R,4S)-8-phenylmenthyl pyruvate 4, and the absolute configuration of acid (+)-2 was unambiguously determined to be S by the 1H NMR anisotropy method.

Original languageEnglish
Pages (from-to)4075-4078
Number of pages4
JournalTetrahedron Asymmetry
Volume10
Issue number21
DOIs
Publication statusPublished - Oct 29 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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