Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the 1H NMR anisotropy method

Akio Ichikawa, Syuntaro Hiradate, Akinori Sugio, Shunsuke Kuwahara, Masataka Watanabe, Nobuyuki Harada

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

2-Methoxy-2-(2-naphthyl)propionic acid 1 and 2-hydroxy-2-(2-naphthyl)propionic acid 2 were prepared by the Grignard reaction of 2-naphthylmagnesium bromide with (1R,2S,5R)-(-)-menthyl pyruvate. The absolute configurations of (+)-1 and (+)-2 were determined to be S by the 1H NMR anisotropy method. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2669-2675
Number of pages7
JournalTetrahedron Asymmetry
Volume11
Issue number13
DOIs
Publication statusPublished - Jul 14 2000
Externally publishedYes

Fingerprint

propionic acid
Propionic acid
Pyruvic Acid
Bromides
Anisotropy
Grignard reactions
Nuclear magnetic resonance
pyruvates
nuclear magnetic resonance
anisotropy
configurations
bromides
2-methoxy-2-(1-naphthyl)propionic acid

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the 1H NMR anisotropy method. / Ichikawa, Akio; Hiradate, Syuntaro; Sugio, Akinori; Kuwahara, Shunsuke; Watanabe, Masataka; Harada, Nobuyuki.

In: Tetrahedron Asymmetry, Vol. 11, No. 13, 14.07.2000, p. 2669-2675.

Research output: Contribution to journalArticle

Ichikawa, Akio ; Hiradate, Syuntaro ; Sugio, Akinori ; Kuwahara, Shunsuke ; Watanabe, Masataka ; Harada, Nobuyuki. / Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the 1H NMR anisotropy method. In: Tetrahedron Asymmetry. 2000 ; Vol. 11, No. 13. pp. 2669-2675.
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