Absolute configuration of 2-methoxy-2-(2-naphthyl)propionic acid as determined by the 1H NMR anisotropy method

Akio Ichikawa, Syuntaro Hiradate, Akinori Sugio, Shunsuke Kuwahara, Masataka Watanabe, Nobuyuki Harada

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

2-Methoxy-2-(2-naphthyl)propionic acid 1 and 2-hydroxy-2-(2-naphthyl)propionic acid 2 were prepared by the Grignard reaction of 2-naphthylmagnesium bromide with (1R,2S,5R)-(-)-menthyl pyruvate. The absolute configurations of (+)-1 and (+)-2 were determined to be S by the 1H NMR anisotropy method. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)2669-2675
Number of pages7
JournalTetrahedron Asymmetry
Volume11
Issue number13
DOIs
Publication statusPublished - Jul 14 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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