Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma

Akira Watanabe, Norihumi Harimoto, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Takahiro Yamanaka, Tomoharu Yoshizumi, Ken Shirabe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Aim: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Therefore, the present study aimed to evaluate the prognostic ability of inflammatory factors. Materials and Methods: Forty-four patients with mass-forming IHCC (m-IHCC) were retrospectively evaluated and the correlations between inflammatory markers, including neutrophil–to–lymphocyte ratio and, modified Glasgow prognostic score, and patient survival were assessed. Results: The absolute neutrophil count (ANC) was significantly higher in the recurrence group than in the non-recurrence group (p=0.00568) and the most significant prognostic factor by multivariate analysis. Poor recurrence-free survival (RFS; p=0.00452) and cancer-specific survival (CSS; p=0.0323) were associated with high neutrophil levels. Moreover, neutrophil infiltration in the tumor site was positively correlated with ANC. Conclusion: ANC is associated with poor RFS, and could be used to predict recurrence in patients with m-IHCC.

Original languageEnglish
Pages (from-to)941-947
Number of pages7
JournalAnticancer research
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Cholangiocarcinoma
Neutrophils
Recurrence
Survival
Neoplasms
Neutrophil Infiltration
Statistical Factor Analysis
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Watanabe, A., Harimoto, N., Araki, K., Kubo, N., Igarashi, T., Tsukagoshi, M., ... Shirabe, K. (2019). Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma. Anticancer research, 39(2), 941-947. https://doi.org/10.21873/anticanres.13197

Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma. / Watanabe, Akira; Harimoto, Norihumi; Araki, Kenichiro; Kubo, Norio; Igarashi, Takamichi; Tsukagoshi, Mariko; Ishii, Norihiro; Yamanaka, Takahiro; Yoshizumi, Tomoharu; Shirabe, Ken.

In: Anticancer research, Vol. 39, No. 2, 01.02.2019, p. 941-947.

Research output: Contribution to journalArticle

Watanabe, A, Harimoto, N, Araki, K, Kubo, N, Igarashi, T, Tsukagoshi, M, Ishii, N, Yamanaka, T, Yoshizumi, T & Shirabe, K 2019, 'Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma', Anticancer research, vol. 39, no. 2, pp. 941-947. https://doi.org/10.21873/anticanres.13197
Watanabe, Akira ; Harimoto, Norihumi ; Araki, Kenichiro ; Kubo, Norio ; Igarashi, Takamichi ; Tsukagoshi, Mariko ; Ishii, Norihiro ; Yamanaka, Takahiro ; Yoshizumi, Tomoharu ; Shirabe, Ken. / Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma. In: Anticancer research. 2019 ; Vol. 39, No. 2. pp. 941-947.
@article{368b6d6817c74f22b819da8df9e96360,
title = "Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma",
abstract = "Background/Aim: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Therefore, the present study aimed to evaluate the prognostic ability of inflammatory factors. Materials and Methods: Forty-four patients with mass-forming IHCC (m-IHCC) were retrospectively evaluated and the correlations between inflammatory markers, including neutrophil–to–lymphocyte ratio and, modified Glasgow prognostic score, and patient survival were assessed. Results: The absolute neutrophil count (ANC) was significantly higher in the recurrence group than in the non-recurrence group (p=0.00568) and the most significant prognostic factor by multivariate analysis. Poor recurrence-free survival (RFS; p=0.00452) and cancer-specific survival (CSS; p=0.0323) were associated with high neutrophil levels. Moreover, neutrophil infiltration in the tumor site was positively correlated with ANC. Conclusion: ANC is associated with poor RFS, and could be used to predict recurrence in patients with m-IHCC.",
author = "Akira Watanabe and Norihumi Harimoto and Kenichiro Araki and Norio Kubo and Takamichi Igarashi and Mariko Tsukagoshi and Norihiro Ishii and Takahiro Yamanaka and Tomoharu Yoshizumi and Ken Shirabe",
year = "2019",
month = "2",
day = "1",
doi = "10.21873/anticanres.13197",
language = "English",
volume = "39",
pages = "941--947",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "2",

}

TY - JOUR

T1 - Absolute neutrophil count predicts postoperative prognosis in mass-forming intrahepatic cholangiocarcinoma

AU - Watanabe, Akira

AU - Harimoto, Norihumi

AU - Araki, Kenichiro

AU - Kubo, Norio

AU - Igarashi, Takamichi

AU - Tsukagoshi, Mariko

AU - Ishii, Norihiro

AU - Yamanaka, Takahiro

AU - Yoshizumi, Tomoharu

AU - Shirabe, Ken

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Background/Aim: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Therefore, the present study aimed to evaluate the prognostic ability of inflammatory factors. Materials and Methods: Forty-four patients with mass-forming IHCC (m-IHCC) were retrospectively evaluated and the correlations between inflammatory markers, including neutrophil–to–lymphocyte ratio and, modified Glasgow prognostic score, and patient survival were assessed. Results: The absolute neutrophil count (ANC) was significantly higher in the recurrence group than in the non-recurrence group (p=0.00568) and the most significant prognostic factor by multivariate analysis. Poor recurrence-free survival (RFS; p=0.00452) and cancer-specific survival (CSS; p=0.0323) were associated with high neutrophil levels. Moreover, neutrophil infiltration in the tumor site was positively correlated with ANC. Conclusion: ANC is associated with poor RFS, and could be used to predict recurrence in patients with m-IHCC.

AB - Background/Aim: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Therefore, the present study aimed to evaluate the prognostic ability of inflammatory factors. Materials and Methods: Forty-four patients with mass-forming IHCC (m-IHCC) were retrospectively evaluated and the correlations between inflammatory markers, including neutrophil–to–lymphocyte ratio and, modified Glasgow prognostic score, and patient survival were assessed. Results: The absolute neutrophil count (ANC) was significantly higher in the recurrence group than in the non-recurrence group (p=0.00568) and the most significant prognostic factor by multivariate analysis. Poor recurrence-free survival (RFS; p=0.00452) and cancer-specific survival (CSS; p=0.0323) were associated with high neutrophil levels. Moreover, neutrophil infiltration in the tumor site was positively correlated with ANC. Conclusion: ANC is associated with poor RFS, and could be used to predict recurrence in patients with m-IHCC.

UR - http://www.scopus.com/inward/record.url?scp=85061012273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061012273&partnerID=8YFLogxK

U2 - 10.21873/anticanres.13197

DO - 10.21873/anticanres.13197

M3 - Article

C2 - 30711979

AN - SCOPUS:85061012273

VL - 39

SP - 941

EP - 947

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 2

ER -