AC susceptibility of magnetic markers in suspension for liquid phase immunoassay

Keiji Enpuku, Tsuyoshi Tanaka, Yuya Tamai, Masaaki Matsuo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

AC susceptibility of magnetic markers in solution was studied for biosensor applications. First, frequency dependence of the susceptibility was measured, and size distribution of the markers was estimated by analyzing the experimental result with the so-called singular value decomposition (SVD) method. The size distribution estimated with the magnetic measurement agreed with that obtained from conventional optical measurement. Next, susceptibility measurement was applied to the liquid-phase immunoassay without bound/free (B/F) separation. We performed the detection of biotin-coated polymer beads in suspension using avidin-coated magnetic markers. Changes of the susceptibility and the size distribution caused by the binding reaction were shown.

Original languageEnglish
Pages (from-to)1621-1624
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume321
Issue number10
DOIs
Publication statusPublished - May 1 2009

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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