Accelerated restoration of the leukocyte number and augmented resistance against Eschericia coli in cyclophosphamide-treated rats orally administered with a hot water extract of Chlorella vulgaris

Takashi Hasegawa, Yasunobu Yoshikai, Masao Okuda, Kikuo Nomoto

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    30 Citations (Scopus)

    Abstract

    The effects of oral administration of a hot water extract of Chlorella vulgaris (CVE) on the restoration of the leukocyte number and on the resistance against Escherichia coli infection were examined in cyclophosphamide (CY)-treated rats. Male Fischer rats (F344/DuCrj) were administered orally 1000 mg/kg of CVE for 14 days and injected intraperitoneally with a single dose of CY (50 mg/kg) (day 0) one day after the 14th CVE administration. CVE was further administered continuously after CY treatment until the rats were sacrificed for analysis. The number of bone marrow cells in the CY + CVE group was significantly higher on day 7 after CY treatment than that in the CY-treated group. The number of spleen cells in the CY + CVE group became significantly higher on day 11 than that in the CY-treated group. In the peripheral blood, the number of PMN recovered efficiently in the CY + CVE group in comparison with the CY-treated group on day 7. When E. coli was injected i.p. into normal, CY-treated, and CY + CVE-treated rats on day 6, the difference in number of bacteria among these three groups was most prominent before 6 h, that is, the number in the CY + CVE group was remarkably lower than those in the CY-treated group, and even in the control group, among all organs so far tested.

    Original languageEnglish
    Pages (from-to)883-891
    Number of pages9
    JournalInternational Journal of Immunopharmacology
    Volume12
    Issue number8
    DOIs
    Publication statusPublished - Jan 1 1990

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    Chlorella vulgaris
    Leukocyte Count
    Cyclophosphamide
    Water
    Escherichia coli Infections
    Inbred F344 Rats

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Pharmacology

    Cite this

    Accelerated restoration of the leukocyte number and augmented resistance against Eschericia coli in cyclophosphamide-treated rats orally administered with a hot water extract of Chlorella vulgaris. / Hasegawa, Takashi; Yoshikai, Yasunobu; Okuda, Masao; Nomoto, Kikuo.

    In: International Journal of Immunopharmacology, Vol. 12, No. 8, 01.01.1990, p. 883-891.

    Research output: Contribution to journalArticle

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    abstract = "The effects of oral administration of a hot water extract of Chlorella vulgaris (CVE) on the restoration of the leukocyte number and on the resistance against Escherichia coli infection were examined in cyclophosphamide (CY)-treated rats. Male Fischer rats (F344/DuCrj) were administered orally 1000 mg/kg of CVE for 14 days and injected intraperitoneally with a single dose of CY (50 mg/kg) (day 0) one day after the 14th CVE administration. CVE was further administered continuously after CY treatment until the rats were sacrificed for analysis. The number of bone marrow cells in the CY + CVE group was significantly higher on day 7 after CY treatment than that in the CY-treated group. The number of spleen cells in the CY + CVE group became significantly higher on day 11 than that in the CY-treated group. In the peripheral blood, the number of PMN recovered efficiently in the CY + CVE group in comparison with the CY-treated group on day 7. When E. coli was injected i.p. into normal, CY-treated, and CY + CVE-treated rats on day 6, the difference in number of bacteria among these three groups was most prominent before 6 h, that is, the number in the CY + CVE group was remarkably lower than those in the CY-treated group, and even in the control group, among all organs so far tested.",
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