Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations

Osamu Togao, Hiwatashi Akio, Koji Yamashita, Daichi Momosaka, Makoto Obara, ataru nishimura, Koichi Arimura, Nobuhiro Hata, Koji Iihara, Marc Van Cauteren, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the performance of acceleration-selective arterial spin labeling (AccASL) MR angiography in the visualization of brain arteriovenous malformations (AVMs) in comparison with digital subtraction angiography (DSA) and time-of-flight (TOF) MR angiography. Methods: Twenty-one patients with brain AVM (mean age 31.1 ± 18.6 years; 11 males, 10 females) underwent TOF and AccASL MR angiography and DSA. Two neuroradiologists conducted an observer study for detection, nidus size, eloquence, venous drainage pattern, and Spetzler-Martin (SM) grade. The evaluations included the visualization of each AVM component with reference to DSA and assessments of contrast-to-noise ratio (CNR). The kappa statistic, repeated measures analysis of variance, Wilcoxon matched pairs test, and paired t test were used. Results: Both observers detected more AVMs with AccASL (95.2%, 90.5% for Observers 1 and 2) than with TOF (76.2% and 71.4%, respectively). The inter-modality agreement between AccASL and DSA was almost perfect for the eloquence, venous drainage pattern, and SM grade for Observer 1 and moderate for the venous drainage pattern and substantial for the eloquence and SM grade for Observer 2. The visualization scores were higher with AccASL than with TOF for the feeding artery (AccASL, 4.5 ± 1.0 vs. TOF, 3.9 ± 1.5, p = 0.0214), nidus (4.6 ± 1.1 vs. 3.2 ± 1.5, p = 0.0006), and draining vein (4.6 ± 1.0 vs. 2.2 ± 1.1, p < 0.0001), respectively. The CNRs in the nidus were higher in AccASL than in TOF (29.9 ± 16.7 vs. 20.8 ± 16.5, p = 0.0002), as in the draining vein (23.2 ± 13.0 vs. 12.6 ± 12.0, p = 0.0010), respectively. Conclusions: AccASL better visualized brain AVMs compared with TOF and was useful for grading without the use of contrast agents.

Original languageEnglish
Pages (from-to)979-989
Number of pages11
JournalNeuroradiology
Volume61
Issue number9
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Arteriovenous Malformations
Angiography
Digital Subtraction Angiography
Brain
Drainage
Veins
Contrast Media
Noise
Analysis of Variance
Arteries

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations. / Togao, Osamu; Akio, Hiwatashi; Yamashita, Koji; Momosaka, Daichi; Obara, Makoto; nishimura, ataru; Arimura, Koichi; Hata, Nobuhiro; Iihara, Koji; Van Cauteren, Marc; Honda, Hiroshi.

In: Neuroradiology, Vol. 61, No. 9, 01.09.2019, p. 979-989.

Research output: Contribution to journalArticle

@article{dc301d1e72b04c28af09b331cbecbbaa,
title = "Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations",
abstract = "Purpose: To evaluate the performance of acceleration-selective arterial spin labeling (AccASL) MR angiography in the visualization of brain arteriovenous malformations (AVMs) in comparison with digital subtraction angiography (DSA) and time-of-flight (TOF) MR angiography. Methods: Twenty-one patients with brain AVM (mean age 31.1 ± 18.6 years; 11 males, 10 females) underwent TOF and AccASL MR angiography and DSA. Two neuroradiologists conducted an observer study for detection, nidus size, eloquence, venous drainage pattern, and Spetzler-Martin (SM) grade. The evaluations included the visualization of each AVM component with reference to DSA and assessments of contrast-to-noise ratio (CNR). The kappa statistic, repeated measures analysis of variance, Wilcoxon matched pairs test, and paired t test were used. Results: Both observers detected more AVMs with AccASL (95.2{\%}, 90.5{\%} for Observers 1 and 2) than with TOF (76.2{\%} and 71.4{\%}, respectively). The inter-modality agreement between AccASL and DSA was almost perfect for the eloquence, venous drainage pattern, and SM grade for Observer 1 and moderate for the venous drainage pattern and substantial for the eloquence and SM grade for Observer 2. The visualization scores were higher with AccASL than with TOF for the feeding artery (AccASL, 4.5 ± 1.0 vs. TOF, 3.9 ± 1.5, p = 0.0214), nidus (4.6 ± 1.1 vs. 3.2 ± 1.5, p = 0.0006), and draining vein (4.6 ± 1.0 vs. 2.2 ± 1.1, p < 0.0001), respectively. The CNRs in the nidus were higher in AccASL than in TOF (29.9 ± 16.7 vs. 20.8 ± 16.5, p = 0.0002), as in the draining vein (23.2 ± 13.0 vs. 12.6 ± 12.0, p = 0.0010), respectively. Conclusions: AccASL better visualized brain AVMs compared with TOF and was useful for grading without the use of contrast agents.",
author = "Osamu Togao and Hiwatashi Akio and Koji Yamashita and Daichi Momosaka and Makoto Obara and ataru nishimura and Koichi Arimura and Nobuhiro Hata and Koji Iihara and {Van Cauteren}, Marc and Hiroshi Honda",
year = "2019",
month = "9",
day = "1",
doi = "10.1007/s00234-019-02217-w",
language = "English",
volume = "61",
pages = "979--989",
journal = "Neuroradiology",
issn = "0028-3940",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Acceleration-selective arterial spin labeling MR angiography for visualization of brain arteriovenous malformations

AU - Togao, Osamu

AU - Akio, Hiwatashi

AU - Yamashita, Koji

AU - Momosaka, Daichi

AU - Obara, Makoto

AU - nishimura, ataru

AU - Arimura, Koichi

AU - Hata, Nobuhiro

AU - Iihara, Koji

AU - Van Cauteren, Marc

AU - Honda, Hiroshi

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Purpose: To evaluate the performance of acceleration-selective arterial spin labeling (AccASL) MR angiography in the visualization of brain arteriovenous malformations (AVMs) in comparison with digital subtraction angiography (DSA) and time-of-flight (TOF) MR angiography. Methods: Twenty-one patients with brain AVM (mean age 31.1 ± 18.6 years; 11 males, 10 females) underwent TOF and AccASL MR angiography and DSA. Two neuroradiologists conducted an observer study for detection, nidus size, eloquence, venous drainage pattern, and Spetzler-Martin (SM) grade. The evaluations included the visualization of each AVM component with reference to DSA and assessments of contrast-to-noise ratio (CNR). The kappa statistic, repeated measures analysis of variance, Wilcoxon matched pairs test, and paired t test were used. Results: Both observers detected more AVMs with AccASL (95.2%, 90.5% for Observers 1 and 2) than with TOF (76.2% and 71.4%, respectively). The inter-modality agreement between AccASL and DSA was almost perfect for the eloquence, venous drainage pattern, and SM grade for Observer 1 and moderate for the venous drainage pattern and substantial for the eloquence and SM grade for Observer 2. The visualization scores were higher with AccASL than with TOF for the feeding artery (AccASL, 4.5 ± 1.0 vs. TOF, 3.9 ± 1.5, p = 0.0214), nidus (4.6 ± 1.1 vs. 3.2 ± 1.5, p = 0.0006), and draining vein (4.6 ± 1.0 vs. 2.2 ± 1.1, p < 0.0001), respectively. The CNRs in the nidus were higher in AccASL than in TOF (29.9 ± 16.7 vs. 20.8 ± 16.5, p = 0.0002), as in the draining vein (23.2 ± 13.0 vs. 12.6 ± 12.0, p = 0.0010), respectively. Conclusions: AccASL better visualized brain AVMs compared with TOF and was useful for grading without the use of contrast agents.

AB - Purpose: To evaluate the performance of acceleration-selective arterial spin labeling (AccASL) MR angiography in the visualization of brain arteriovenous malformations (AVMs) in comparison with digital subtraction angiography (DSA) and time-of-flight (TOF) MR angiography. Methods: Twenty-one patients with brain AVM (mean age 31.1 ± 18.6 years; 11 males, 10 females) underwent TOF and AccASL MR angiography and DSA. Two neuroradiologists conducted an observer study for detection, nidus size, eloquence, venous drainage pattern, and Spetzler-Martin (SM) grade. The evaluations included the visualization of each AVM component with reference to DSA and assessments of contrast-to-noise ratio (CNR). The kappa statistic, repeated measures analysis of variance, Wilcoxon matched pairs test, and paired t test were used. Results: Both observers detected more AVMs with AccASL (95.2%, 90.5% for Observers 1 and 2) than with TOF (76.2% and 71.4%, respectively). The inter-modality agreement between AccASL and DSA was almost perfect for the eloquence, venous drainage pattern, and SM grade for Observer 1 and moderate for the venous drainage pattern and substantial for the eloquence and SM grade for Observer 2. The visualization scores were higher with AccASL than with TOF for the feeding artery (AccASL, 4.5 ± 1.0 vs. TOF, 3.9 ± 1.5, p = 0.0214), nidus (4.6 ± 1.1 vs. 3.2 ± 1.5, p = 0.0006), and draining vein (4.6 ± 1.0 vs. 2.2 ± 1.1, p < 0.0001), respectively. The CNRs in the nidus were higher in AccASL than in TOF (29.9 ± 16.7 vs. 20.8 ± 16.5, p = 0.0002), as in the draining vein (23.2 ± 13.0 vs. 12.6 ± 12.0, p = 0.0010), respectively. Conclusions: AccASL better visualized brain AVMs compared with TOF and was useful for grading without the use of contrast agents.

UR - http://www.scopus.com/inward/record.url?scp=85064699552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064699552&partnerID=8YFLogxK

U2 - 10.1007/s00234-019-02217-w

DO - 10.1007/s00234-019-02217-w

M3 - Article

VL - 61

SP - 979

EP - 989

JO - Neuroradiology

JF - Neuroradiology

SN - 0028-3940

IS - 9

ER -