Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia

Hiroshi Yagasaki, Seiji Kojima, Hiromasa Yabe, Koji Kato, Hisato Kigasawa, Hisashi Sakamaki, Masahiro Tsuchida, Shunichi Kato, Takakazu Kawase, Yasuo Morishima, Yoshihisa Kodera

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    We retrospectively analyzed the effect of HLA mismatching (HLA-A, -B, -C, -DRB1, -DQB1) with molecular typing on transplantation outcome for 301 patients with acquired severe aplastic anemia (SAA) who received an unrelated BM transplant through the Japan Marrow Donor Program. Additional effect of HLA-DPB1 mismatching was analyzed for 10 of 10 or 9 of 10 HLA allele-matched pairs (n = 169). Of the 301 recipient/donor pairs, 101 (33.6%) were completely matched at 10 of 10 alleles, 69 (23%) were mismatched at 1 allele, and 131 (43.5%) were mismatched at ≥ 2 alleles. Subjects were classified into 5 subgroups: complete match group (group I); singleallele mismatch group (groups II and III); multiple alleles restricted to HLA-C, -DRB1, and -DQB1 mismatch group (group IV); and others (group V). Multivariate analysis indicated that only HLA disparity of group V was a significant risk factor for poor survival and grade II-IV acute GVHD. HLA-DPB1 mismatching was not associated with any clinical outcome. We recommend the use of an HLA 10 of 10 allele-matched unrelated donor. However, if such a donor is not available, any single-allele or multiple-allele (HLA-C, -DRB1, -DQB1) mismatched donor is acceptable as an unrelated donor for patients with severe aplastic anemia.

    Original languageEnglish
    Pages (from-to)3186-3190
    Number of pages5
    JournalBlood
    Volume118
    Issue number11
    DOIs
    Publication statusPublished - Sep 15 2011

    Fingerprint

    HLA-C Antigens
    Unrelated Donors
    Aplastic Anemia
    Bone Marrow Transplantation
    Bone
    Alleles
    Transplants
    HLA-A Antigens
    Tissue Donors
    HLA-DRB1 Chains
    Molecular Typing
    HLA-B Antigens
    HLA-DPB1 antigen
    Japan
    Multivariate Analysis
    Transplantation
    Bone Marrow
    Survival

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

    Cite this

    Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia. / Yagasaki, Hiroshi; Kojima, Seiji; Yabe, Hiromasa; Kato, Koji; Kigasawa, Hisato; Sakamaki, Hisashi; Tsuchida, Masahiro; Kato, Shunichi; Kawase, Takakazu; Morishima, Yasuo; Kodera, Yoshihisa.

    In: Blood, Vol. 118, No. 11, 15.09.2011, p. 3186-3190.

    Research output: Contribution to journalArticle

    Yagasaki, H, Kojima, S, Yabe, H, Kato, K, Kigasawa, H, Sakamaki, H, Tsuchida, M, Kato, S, Kawase, T, Morishima, Y & Kodera, Y 2011, 'Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia', Blood, vol. 118, no. 11, pp. 3186-3190. https://doi.org/10.1182/blood-2011-04-349316
    Yagasaki, Hiroshi ; Kojima, Seiji ; Yabe, Hiromasa ; Kato, Koji ; Kigasawa, Hisato ; Sakamaki, Hisashi ; Tsuchida, Masahiro ; Kato, Shunichi ; Kawase, Takakazu ; Morishima, Yasuo ; Kodera, Yoshihisa. / Acceptable HLA-mismatching in unrelated donor bone marrow transplantation for patients with acquired severe aplastic anemia. In: Blood. 2011 ; Vol. 118, No. 11. pp. 3186-3190.
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