Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum

S. Okuda, K. Taniguchi, C. Kubo, K. Nomoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary in vivo production of antibody to sheep red blood cells (SRBC) was consistently suppressed in EL 4 tumor-bearing C57BL/6 mice, but the secondary response was not suppressed. This suppressed primary in vivo production of antibody was partially restored by systemic administration of Corynebacterium parvum. For investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of C. parvum, the accessory cell function of adherent cells from tumor-bearing mice and C. parvum-treated tumor-bearing mice in in vitro cultures was studied. Peritoneal and splenic cells from tumor-bearing mice were less efficient in promoting in vitro production of antibody to SRBC by macrophage-depleted normal nonadherent cells than the adherent cells from normal mice. C. parvum treatment restored the accessory cell function of splenic adherent cells from tumor-bearing mice but not that of peritoneal cells. Furthermore, adherent cells from tumor-bearing mice did not show suppressive activity against the in vitro plaque-forming cell response.

Original languageEnglish
Pages (from-to)1293-1297
Number of pages5
JournalJournal of the National Cancer Institute
Volume69
Issue number6
Publication statusPublished - Dec 1 1982

Fingerprint

Propionibacterium acnes
Neoplasms
Antibody Formation
Sheep
Erythrocytes
Inbred C57BL Mouse
Immunosuppression
Macrophages

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum. / Okuda, S.; Taniguchi, K.; Kubo, C.; Nomoto, K.

In: Journal of the National Cancer Institute, Vol. 69, No. 6, 01.12.1982, p. 1293-1297.

Research output: Contribution to journalArticle

@article{cfa469f120d642579bcd8cbf6a4a87fb,
title = "Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum",
abstract = "Primary in vivo production of antibody to sheep red blood cells (SRBC) was consistently suppressed in EL 4 tumor-bearing C57BL/6 mice, but the secondary response was not suppressed. This suppressed primary in vivo production of antibody was partially restored by systemic administration of Corynebacterium parvum. For investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of C. parvum, the accessory cell function of adherent cells from tumor-bearing mice and C. parvum-treated tumor-bearing mice in in vitro cultures was studied. Peritoneal and splenic cells from tumor-bearing mice were less efficient in promoting in vitro production of antibody to SRBC by macrophage-depleted normal nonadherent cells than the adherent cells from normal mice. C. parvum treatment restored the accessory cell function of splenic adherent cells from tumor-bearing mice but not that of peritoneal cells. Furthermore, adherent cells from tumor-bearing mice did not show suppressive activity against the in vitro plaque-forming cell response.",
author = "S. Okuda and K. Taniguchi and C. Kubo and K. Nomoto",
year = "1982",
month = "12",
day = "1",
language = "English",
volume = "69",
pages = "1293--1297",
journal = "Journal of the National Cancer Institute",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Accessory cell function in tumor-bearing mice and effects of Corynebacterium parvum

AU - Okuda, S.

AU - Taniguchi, K.

AU - Kubo, C.

AU - Nomoto, K.

PY - 1982/12/1

Y1 - 1982/12/1

N2 - Primary in vivo production of antibody to sheep red blood cells (SRBC) was consistently suppressed in EL 4 tumor-bearing C57BL/6 mice, but the secondary response was not suppressed. This suppressed primary in vivo production of antibody was partially restored by systemic administration of Corynebacterium parvum. For investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of C. parvum, the accessory cell function of adherent cells from tumor-bearing mice and C. parvum-treated tumor-bearing mice in in vitro cultures was studied. Peritoneal and splenic cells from tumor-bearing mice were less efficient in promoting in vitro production of antibody to SRBC by macrophage-depleted normal nonadherent cells than the adherent cells from normal mice. C. parvum treatment restored the accessory cell function of splenic adherent cells from tumor-bearing mice but not that of peritoneal cells. Furthermore, adherent cells from tumor-bearing mice did not show suppressive activity against the in vitro plaque-forming cell response.

AB - Primary in vivo production of antibody to sheep red blood cells (SRBC) was consistently suppressed in EL 4 tumor-bearing C57BL/6 mice, but the secondary response was not suppressed. This suppressed primary in vivo production of antibody was partially restored by systemic administration of Corynebacterium parvum. For investigation of the mechanism of the immunosuppression in tumor-bearing mice and the effects of C. parvum, the accessory cell function of adherent cells from tumor-bearing mice and C. parvum-treated tumor-bearing mice in in vitro cultures was studied. Peritoneal and splenic cells from tumor-bearing mice were less efficient in promoting in vitro production of antibody to SRBC by macrophage-depleted normal nonadherent cells than the adherent cells from normal mice. C. parvum treatment restored the accessory cell function of splenic adherent cells from tumor-bearing mice but not that of peritoneal cells. Furthermore, adherent cells from tumor-bearing mice did not show suppressive activity against the in vitro plaque-forming cell response.

UR - http://www.scopus.com/inward/record.url?scp=0020463742&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020463742&partnerID=8YFLogxK

M3 - Article

C2 - 6292563

AN - SCOPUS:0020463742

VL - 69

SP - 1293

EP - 1297

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

SN - 0027-8874

IS - 6

ER -