Accumulation of αB-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5′-flanking and coding sequence of the genomic DNA

Akiko Iwaki, Toru Iwaki, James E. Goldman, Koji Ogomori, Jun Tateishi, Yoshiyuki Sakaki

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

αB-Crystallin is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease. To examine whether or not accumulation of αB-crystallin is due to any abnormality of the gene structures, we determined the sequence of the αB-crystallin gene in two cases of pathologically confirmed Alexander's disease. Direct sequencing of the promoter and coding regions of the αB-crystallin gene in patients revealed them to have a normal sequence. Northern blotting showed a single αB-crystallin mRNA species expressed in the Alexander's disease brain.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalNeuroscience Letters
Volume140
Issue number1
DOIs
Publication statusPublished - Jun 8 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Accumulation of αB-crystallin in brains of patients with Alexander's disease is not due to an abnormality of the 5′-flanking and coding sequence of the genomic DNA'. Together they form a unique fingerprint.

  • Cite this