Accumulation of MDM2 in pleomorphic xanthoastrocytomas

Kenichi Matsumoto, Satoshi O. Suzuki, Masashi Fukui, Toru Iwaki

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The molecular genetic basis and the tumorigenic mechanism of pleomorphic xanthoastrocytoma (PXA) still remain to be elucidated. The amplification of the mdm2 gene and accumulation of the MDM2 protein, which is considered to be one of the major cellular regulators of p53-mediated cell growth control, were studied in eight specimens of PXA obtained from five patients. All of the PXA samples showed at least focal immunopositivity for MDM2. However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalPathology International
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 1 2004

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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