TY - JOUR
T1 - Accumulation of Neurofilaments in a Sporadic Case of Amyotrophic Lateral Sclerosis
AU - Kondo, Akira
AU - Iwaki, Toru
AU - Tateishi, Jun
AU - Kirimoto, Kohji
AU - Morimoto, Tadao
AU - Oomura, Ichirou
PY - 1986/12
Y1 - 1986/12
N2 - Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.
AB - Abstract: We report a case of sporadic amyotrophic lateral sclerosis (ALS) characterized by a marked accumulation of neurofilaments in the cytoplasm of neurons. The neurofilament was identified by immunohistochemical and electron microscopic studies. The distribution of the accumulation in this case was unique, not only in the motoneurons of the anterior horn but also in the neurons of the other areas of the spinal gray matter, some nuclei in the brain stem, pontine reticular formation, substantia nigra, dentate nucleus in the cerebellum and pyramidal cells in the motor cortex. These observations shed light on the pathogenesis of ALS.
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U2 - 10.1111/j.1440-1819.1986.tb03184.x
DO - 10.1111/j.1440-1819.1986.tb03184.x
M3 - Article
C2 - 3110473
AN - SCOPUS:0022894641
VL - 40
SP - 677
EP - 684
JO - Psychiatry and Clinical Neurosciences
JF - Psychiatry and Clinical Neurosciences
SN - 1323-1316
IS - 4
ER -
