Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations

Yuji Tsutsui, Daisuke Kidera, Takafumi Taniguchi, Go Akamatsu, Isao Komiya, Yoshiyuki Umezu, Yoshiyuki Kitamura, Shingo Baba, Masayuki Sasaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis.

Method: We used a NEMA IEC body phantom filled with an 18F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were acquired in a motionless and moving state on a Biograph mCT. The respiratory movements were simulated by four different waveform patterns consisting of ideal breathing, breathing with a pause period, breathing with a variable amplitude and breathing with a changing baseline. AG-PET selects the narrow bandwidth containing 20 % of the respiratory cycle. PG-PET was reconstructed with five gates. The image quality was physically assessed using the percent contrast (QH,10mm), background variability (N10mm) recovery coefficient (RC), and sphere volumes.

Result: In regular motion patterns with ideal breathing and breathing with a pause period, the QH,10mm, RC and sphere volumes were not different between AG-PET and PG-PET. In the variable amplitude pattern, the QH,10mm of AG-PET was higher than that of PG-PET (35.8 vs 28.2 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.4 vs 8.6 mL). In the changing baseline pattern, the QH,10mm of AG-PET was higher than that of PG-PET (42.4 vs 16.7 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.2 vs 9.8 mL). The N10mm did not differ between AG-PET and PG-PET, irrespective of the motion pattern.

Conclusion: Amplitude gating PET is considered to be more accurate than phase gating PET for examining unstable respiratory motion patterns, such as those involving a variable amplitude or changing baseline.

Original languageEnglish
Pages (from-to)770-779
Number of pages10
JournalAnnals of Nuclear Medicine
Volume28
Issue number8
DOIs
Publication statusPublished - Oct 16 2014

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Respiration
Radioactivity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations. / Tsutsui, Yuji; Kidera, Daisuke; Taniguchi, Takafumi; Akamatsu, Go; Komiya, Isao; Umezu, Yoshiyuki; Kitamura, Yoshiyuki; Baba, Shingo; Sasaki, Masayuki.

In: Annals of Nuclear Medicine, Vol. 28, No. 8, 16.10.2014, p. 770-779.

Research output: Contribution to journalArticle

Tsutsui Y, Kidera D, Taniguchi T, Akamatsu G, Komiya I, Umezu Y et al. Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations. Annals of Nuclear Medicine. 2014 Oct 16;28(8):770-779. https://doi.org/10.1007/s12149-014-0870-5
Tsutsui, Yuji ; Kidera, Daisuke ; Taniguchi, Takafumi ; Akamatsu, Go ; Komiya, Isao ; Umezu, Yoshiyuki ; Kitamura, Yoshiyuki ; Baba, Shingo ; Sasaki, Masayuki. / Accuracy of amplitude-based respiratory gating for PET/CT in irregular respirations. In: Annals of Nuclear Medicine. 2014 ; Vol. 28, No. 8. pp. 770-779.
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abstract = "Objective: We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis.Method: We used a NEMA IEC body phantom filled with an 18F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were acquired in a motionless and moving state on a Biograph mCT. The respiratory movements were simulated by four different waveform patterns consisting of ideal breathing, breathing with a pause period, breathing with a variable amplitude and breathing with a changing baseline. AG-PET selects the narrow bandwidth containing 20 {\%} of the respiratory cycle. PG-PET was reconstructed with five gates. The image quality was physically assessed using the percent contrast (QH,10mm), background variability (N10mm) recovery coefficient (RC), and sphere volumes.Result: In regular motion patterns with ideal breathing and breathing with a pause period, the QH,10mm, RC and sphere volumes were not different between AG-PET and PG-PET. In the variable amplitude pattern, the QH,10mm of AG-PET was higher than that of PG-PET (35.8 vs 28.2 {\%}), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.4 vs 8.6 mL). In the changing baseline pattern, the QH,10mm of AG-PET was higher than that of PG-PET (42.4 vs 16.7 {\%}), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.2 vs 9.8 mL). The N10mm did not differ between AG-PET and PG-PET, irrespective of the motion pattern.Conclusion: Amplitude gating PET is considered to be more accurate than phase gating PET for examining unstable respiratory motion patterns, such as those involving a variable amplitude or changing baseline.",
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AU - Tsutsui, Yuji

AU - Kidera, Daisuke

AU - Taniguchi, Takafumi

AU - Akamatsu, Go

AU - Komiya, Isao

AU - Umezu, Yoshiyuki

AU - Kitamura, Yoshiyuki

AU - Baba, Shingo

AU - Sasaki, Masayuki

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Y1 - 2014/10/16

N2 - Objective: We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis.Method: We used a NEMA IEC body phantom filled with an 18F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were acquired in a motionless and moving state on a Biograph mCT. The respiratory movements were simulated by four different waveform patterns consisting of ideal breathing, breathing with a pause period, breathing with a variable amplitude and breathing with a changing baseline. AG-PET selects the narrow bandwidth containing 20 % of the respiratory cycle. PG-PET was reconstructed with five gates. The image quality was physically assessed using the percent contrast (QH,10mm), background variability (N10mm) recovery coefficient (RC), and sphere volumes.Result: In regular motion patterns with ideal breathing and breathing with a pause period, the QH,10mm, RC and sphere volumes were not different between AG-PET and PG-PET. In the variable amplitude pattern, the QH,10mm of AG-PET was higher than that of PG-PET (35.8 vs 28.2 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.4 vs 8.6 mL). In the changing baseline pattern, the QH,10mm of AG-PET was higher than that of PG-PET (42.4 vs 16.7 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.2 vs 9.8 mL). The N10mm did not differ between AG-PET and PG-PET, irrespective of the motion pattern.Conclusion: Amplitude gating PET is considered to be more accurate than phase gating PET for examining unstable respiratory motion patterns, such as those involving a variable amplitude or changing baseline.

AB - Objective: We evaluated the accuracy of amplitude gating PET (AG-PET) compared with phase gating PET (PG-PET) in relation to respiratory motion patterns based on a phantom analysis.Method: We used a NEMA IEC body phantom filled with an 18F solution with a 4:1 sphere-to-background radioactivity ratio (12.6 and 2.97 kBq/mL). PET/CT scans were acquired in a motionless and moving state on a Biograph mCT. The respiratory movements were simulated by four different waveform patterns consisting of ideal breathing, breathing with a pause period, breathing with a variable amplitude and breathing with a changing baseline. AG-PET selects the narrow bandwidth containing 20 % of the respiratory cycle. PG-PET was reconstructed with five gates. The image quality was physically assessed using the percent contrast (QH,10mm), background variability (N10mm) recovery coefficient (RC), and sphere volumes.Result: In regular motion patterns with ideal breathing and breathing with a pause period, the QH,10mm, RC and sphere volumes were not different between AG-PET and PG-PET. In the variable amplitude pattern, the QH,10mm of AG-PET was higher than that of PG-PET (35.8 vs 28.2 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.4 vs 8.6 mL). In the changing baseline pattern, the QH,10mm of AG-PET was higher than that of PG-PET (42.4 vs 16.7 %), the RC of AG-PET was higher than that of PG-PET and sphere volume of AG-PET was smaller than that of PG-PET (6.2 vs 9.8 mL). The N10mm did not differ between AG-PET and PG-PET, irrespective of the motion pattern.Conclusion: Amplitude gating PET is considered to be more accurate than phase gating PET for examining unstable respiratory motion patterns, such as those involving a variable amplitude or changing baseline.

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