Acid-catalyzed Nazarov reaction controlled by β-alkoxy groups

Mitsuru Shindo, Kentaro Yaji, Taisuke Kita, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Acid-catalyzed Nazarov reaction of β-alkoxy divinyl ketones providing 5-oxycyclopent-2-enones has been developed. The effects of the β-alkoxy group on the catalyst efficiency and the regioselectivity are based on the stabilization of the intermediates and the spontaneous elimination of the group followed by trapping. The substrates are easily accessible using the torquoselective olefination of esters with ynolates.

Original languageEnglish
Pages (from-to)1096-1100
Number of pages5
Issue number7
Publication statusPublished - Apr 24 2007

All Science Journal Classification (ASJC) codes

  • Organic Chemistry


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