Acquired hemophilia in a patient with systemic lupus erythematosus: A case report and literature review

Mitsuteru Akahoshi, Kumiko Aizawa, Shuji Nagano, Hisako Inoue, Atsushi Sadanaga, Yojiro Arinobu, Hiroaki Niiro, Hitoshi Nakashima

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We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) who developed acquired hemophilia caused by factor VIII (FVIII) inhibitors. She manifested spontaneous bleeding symptoms such as ecchymoses and hematuria. Laboratory findings showed an isolated prolongation of the activated partial thromboplastin time, reduced FVIII activity, and a high titer of FVIII inhibitors. She was successfully treated with oral predonisolone and cyclosporine in combination with steroid and cyclophosphamide pulse therapy.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalModern Rheumatology
Issue number5
Publication statusPublished - Jun 13 2008


All Science Journal Classification (ASJC) codes

  • Rheumatology

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