Activation and alteration of base selectivity by metal cations in the functionality-transfer reaction for RNA modification

Kazumitsu Onizuka, Yosuke Taniguchi, Shigeki Sasaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that its selectivity was changed to the guanine base at pH 9.6. In this study, it was found that the functionality-transfer reaction enhanced selectivity for the guanine base in the presence of divalent transition metal cations such as Ni2+ and Co2+ at pH 7.4.

Original languageEnglish
Pages (from-to)1508-1512
Number of pages5
JournalBioconjugate Chemistry
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 18 2010

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

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