Activation of inward current associated with M-potassium current inhibition in m1-muscarinic receptor-transformed NG108-15 cells by KST-5452, a novel cognition enhancer

Hideyuki Kishida, Kozo Yamamoto, Yoshihide Fuse, Mami Noda, Haruhiro Higashida

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The electrophysiological effects of KST-5452 [3-(m-phenoxybenzylidene)-quinuclidine], an M1 muscarinic acetylcholine receptor (muscarinic AChR) binding compound, were studied in NG108-15 neuroblastoma × glioma hybrid cells transfected with ml muscarinic AChR cDNA. Application of KST-5452 to m1-transformed NGPM1-27 cells elicited a sustained inward current associated with decreased conductance and reduced M-current relaxations at a holding potential of -20 mV. The KST-5452-induced responses were blocked by pirenzepine, suggesting that KST-5452 acts as a potent excitant via M1 muscarinic AChRs in brain neurons.

Original languageEnglish
Pages (from-to)119-121
Number of pages3
JournalNeuroscience Letters
Volume172
Issue number1-2
DOIs
Publication statusPublished - May 19 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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