TY - JOUR
T1 - Activation of protein splicing by protease- or light-triggered O to N acyl migration
AU - Vila-Perelló, Miquel
AU - Hori, Yuichiro
AU - Ribó, Marc
AU - Muir, Tom W.
PY - 2008/9/22
Y1 - 2008/9/22
N2 - Protein splicing under control: Introduction of an O-acyl isomer of a peptide bond into the naturally split Ssp DnaE intein prevents protein trans splicing, which can be recovered upon triggering an O to N acyl shift by deprotection with protease or light (see scheme). This system allows the splicing of a bacterial toxin to be controlled in response to protease activity.
AB - Protein splicing under control: Introduction of an O-acyl isomer of a peptide bond into the naturally split Ssp DnaE intein prevents protein trans splicing, which can be recovered upon triggering an O to N acyl shift by deprotection with protease or light (see scheme). This system allows the splicing of a bacterial toxin to be controlled in response to protease activity.
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U2 - 10.1002/anie.200802502
DO - 10.1002/anie.200802502
M3 - Article
C2 - 18767096
AN - SCOPUS:54749102251
VL - 47
SP - 7764
EP - 7767
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 40
ER -