Active control of bubble liposome through artificial capillary by using matrix array transducer

Ren Koda, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We have ever reported our attempts to control microbubbles (MBs) using the primary and secondary acoustic force for active control in artificial blood vessels. Recently, we have demonstrated active path selection of MBs by using a matrix array transducer to produce multiple focal points. On the other hand, bubble liposomes (BLs) have an advantage in easily modifying targeting ligand. However, considering that BLs are several hundred nanometers in diameter, there were some difficulties in controllability of bubbles in blood flow under ultrasound exposure, since acoustic forces are less affected to these small bubbles. In this study, we used the liposomes (BLs) entrapping perfluoropropane gas with the average diameter of 500 nm and applied it to control the behavior in an artificial blood vessel. First, we observed aggregates formation of BLs in static water by secondary acoustic force. Next, we investigated the BLs control in multi-bifurcated flow by using a matrix array transducer. As a result, the streaming of BLs was viscously propelled to a desired path. BLs are much tied each other because of surface interaction of the lipid membrane and then caused a resistance to flow compare to MBs.

    Original languageEnglish
    Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
    Pages2099-2102
    Number of pages4
    DOIs
    Publication statusPublished - Dec 1 2013
    Event2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
    Duration: Jul 21 2013Jul 25 2013

    Publication series

    NameIEEE International Ultrasonics Symposium, IUS
    ISSN (Print)1948-5719
    ISSN (Electronic)1948-5727

    Other

    Other2013 IEEE International Ultrasonics Symposium, IUS 2013
    Country/TerritoryCzech Republic
    CityPrague
    Period7/21/137/25/13

    All Science Journal Classification (ASJC) codes

    • Acoustics and Ultrasonics

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