Active heavy cigarette smoking is associated with poor survival in Japanese patients with advanced renal cell carcinoma: Sub-analysis of the multi-institutional national database of the Japanese Urological Association

the Cancer Registration Committee of the Japanese Urological Association

Research output: Contribution to journalArticle

Abstract

Objective: The association between cigarette smoking and survival in patients with renal cell carcinoma is not well studied. We examined the impact of cigarette smoking on survival of patients with advanced renal cell carcinoma using the multi-institutional national database of the Japanese Urological Association. Methods: From 340 Japanese institutions, 963 patients with renal cell carcinoma of clinical Stage 3 or higher were analyzed. Univariate analysis using the Kaplan-Meier method and multivariate Cox regression models with stepwise selection was used to evaluate overall and causespecific survival. Results: Median duration of follow-up was 842 days, and overall and cancer death occurred in 392 (40.7%) and 351 (36.4%) patients, respectively. In multivariate analysis, smoking 20 or more cigarettes daily at diagnosis was associated with poorer overall and cancer-specific survival, especially in Stage 3. According to a Cox proportional hazards model, heavy cigarette smoking at diagnosis and the variables of underweight, fever symptoms, serum lactic dehydrogenase value, serum C-reactive protein value, serum creatinine value, Eastern Cooperative Oncology Group performance status, nephrectomy and clinical stage were significant (P < 0.05) for overall and cancer-specific survival. Conclusions: We could compare the smoking status at diagnosis and the prognosis of renal cell carcinoma at national wide scale. Heavy active smoking was an independent prognostic factor for overall and cancer-specific survival in patients with advanced renal cell carcinoma, especially in Stage 3.

Original languageEnglish
Pages (from-to)1162-1169
Number of pages8
JournalJapanese journal of clinical oncology
Volume47
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

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Renal Cell Carcinoma
Smoking
Databases
Survival
Proportional Hazards Models
Neoplasms
Thinness
Kaplan-Meier Estimate
Nephrectomy
Serum
Tobacco Products
C-Reactive Protein
Blood Proteins
Creatinine
Oxidoreductases
Milk
Fever
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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Active heavy cigarette smoking is associated with poor survival in Japanese patients with advanced renal cell carcinoma : Sub-analysis of the multi-institutional national database of the Japanese Urological Association. / the Cancer Registration Committee of the Japanese Urological Association.

In: Japanese journal of clinical oncology, Vol. 47, No. 12, 01.12.2017, p. 1162-1169.

Research output: Contribution to journalArticle

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title = "Active heavy cigarette smoking is associated with poor survival in Japanese patients with advanced renal cell carcinoma: Sub-analysis of the multi-institutional national database of the Japanese Urological Association",
abstract = "Objective: The association between cigarette smoking and survival in patients with renal cell carcinoma is not well studied. We examined the impact of cigarette smoking on survival of patients with advanced renal cell carcinoma using the multi-institutional national database of the Japanese Urological Association. Methods: From 340 Japanese institutions, 963 patients with renal cell carcinoma of clinical Stage 3 or higher were analyzed. Univariate analysis using the Kaplan-Meier method and multivariate Cox regression models with stepwise selection was used to evaluate overall and causespecific survival. Results: Median duration of follow-up was 842 days, and overall and cancer death occurred in 392 (40.7{\%}) and 351 (36.4{\%}) patients, respectively. In multivariate analysis, smoking 20 or more cigarettes daily at diagnosis was associated with poorer overall and cancer-specific survival, especially in Stage 3. According to a Cox proportional hazards model, heavy cigarette smoking at diagnosis and the variables of underweight, fever symptoms, serum lactic dehydrogenase value, serum C-reactive protein value, serum creatinine value, Eastern Cooperative Oncology Group performance status, nephrectomy and clinical stage were significant (P < 0.05) for overall and cancer-specific survival. Conclusions: We could compare the smoking status at diagnosis and the prognosis of renal cell carcinoma at national wide scale. Heavy active smoking was an independent prognostic factor for overall and cancer-specific survival in patients with advanced renal cell carcinoma, especially in Stage 3.",
author = "{the Cancer Registration Committee of the Japanese Urological Association} and Tomohiko Hara and Hiroyuki Fujimoto and Tsunenori Kondo and Nobuo Shinohara and Wataru Obara and Go Kimura and Haruki Kume and Norio Nonomura and Fumiya Hongo and Takayuki Sugiyama and Kanayama, {Hiro omi} and Masayuki Takahashi and Tomoharu Fukumori and Masatoshi Eto",
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T1 - Active heavy cigarette smoking is associated with poor survival in Japanese patients with advanced renal cell carcinoma

T2 - Sub-analysis of the multi-institutional national database of the Japanese Urological Association

AU - the Cancer Registration Committee of the Japanese Urological Association

AU - Hara, Tomohiko

AU - Fujimoto, Hiroyuki

AU - Kondo, Tsunenori

AU - Shinohara, Nobuo

AU - Obara, Wataru

AU - Kimura, Go

AU - Kume, Haruki

AU - Nonomura, Norio

AU - Hongo, Fumiya

AU - Sugiyama, Takayuki

AU - Kanayama, Hiro omi

AU - Takahashi, Masayuki

AU - Fukumori, Tomoharu

AU - Eto, Masatoshi

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Objective: The association between cigarette smoking and survival in patients with renal cell carcinoma is not well studied. We examined the impact of cigarette smoking on survival of patients with advanced renal cell carcinoma using the multi-institutional national database of the Japanese Urological Association. Methods: From 340 Japanese institutions, 963 patients with renal cell carcinoma of clinical Stage 3 or higher were analyzed. Univariate analysis using the Kaplan-Meier method and multivariate Cox regression models with stepwise selection was used to evaluate overall and causespecific survival. Results: Median duration of follow-up was 842 days, and overall and cancer death occurred in 392 (40.7%) and 351 (36.4%) patients, respectively. In multivariate analysis, smoking 20 or more cigarettes daily at diagnosis was associated with poorer overall and cancer-specific survival, especially in Stage 3. According to a Cox proportional hazards model, heavy cigarette smoking at diagnosis and the variables of underweight, fever symptoms, serum lactic dehydrogenase value, serum C-reactive protein value, serum creatinine value, Eastern Cooperative Oncology Group performance status, nephrectomy and clinical stage were significant (P < 0.05) for overall and cancer-specific survival. Conclusions: We could compare the smoking status at diagnosis and the prognosis of renal cell carcinoma at national wide scale. Heavy active smoking was an independent prognostic factor for overall and cancer-specific survival in patients with advanced renal cell carcinoma, especially in Stage 3.

AB - Objective: The association between cigarette smoking and survival in patients with renal cell carcinoma is not well studied. We examined the impact of cigarette smoking on survival of patients with advanced renal cell carcinoma using the multi-institutional national database of the Japanese Urological Association. Methods: From 340 Japanese institutions, 963 patients with renal cell carcinoma of clinical Stage 3 or higher were analyzed. Univariate analysis using the Kaplan-Meier method and multivariate Cox regression models with stepwise selection was used to evaluate overall and causespecific survival. Results: Median duration of follow-up was 842 days, and overall and cancer death occurred in 392 (40.7%) and 351 (36.4%) patients, respectively. In multivariate analysis, smoking 20 or more cigarettes daily at diagnosis was associated with poorer overall and cancer-specific survival, especially in Stage 3. According to a Cox proportional hazards model, heavy cigarette smoking at diagnosis and the variables of underweight, fever symptoms, serum lactic dehydrogenase value, serum C-reactive protein value, serum creatinine value, Eastern Cooperative Oncology Group performance status, nephrectomy and clinical stage were significant (P < 0.05) for overall and cancer-specific survival. Conclusions: We could compare the smoking status at diagnosis and the prognosis of renal cell carcinoma at national wide scale. Heavy active smoking was an independent prognostic factor for overall and cancer-specific survival in patients with advanced renal cell carcinoma, especially in Stage 3.

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