Active sodium-potassium transports in skeletal muscles of deoxycorticosterone hypertensive rats

Ryoji Nagaoka, Satoru Yamashita, Tooru Maruyama, Norio Akaike

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

CNS-induced suppressions of active Na+,K+ transport was investigated in both 'tonic' muscle, soleus (SOL), and 'twitch' muscle, extensor digitorum longus (EDL) of deoxycorticosterone acetate (DOCA) hypertensive rats. There was a marked K+ loss and Na+ accumulation in the skeletal and smooth muscles of DOCA hypertensive rats. The cellular K+ loss was in the order of SOL > EDL > diaphragm > intestine > aorta. However, liver, kidney and CNS organs such as cerebrum, cerebellum and medulla oblongata were spared from this K+ fall. Sciatic nerve sectioning or cervical transection activated the active Na+, K+ transport in SOL during DOCA hypertension but inhibited further the pump activity in EDL. The application of tetrodotoxin on the sciatic nerve also activated the Na+, K+ transport in SOL but inhibited the transport in EDL. The facilitatory effect of denervation on the pump activity in SOL was abolished by pretreatment with ouabain. Injection of curare had no effect on Na+ and K+ contents in both SOL and EDL. These results indicate that the CNS is involved differently on the neural regulations of the active Na+, K+ transport systems in SOL and EDL of DOCA hypertensive rats.

Original languageEnglish
Pages (from-to)283-291
Number of pages9
JournalBrain Research
Volume410
Issue number2
DOIs
Publication statusPublished - May 5 1987

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Active sodium-potassium transports in skeletal muscles of deoxycorticosterone hypertensive rats'. Together they form a unique fingerprint.

  • Cite this