Activin A inhibits differentiation of chick myogenic cells in vitro

Masataka Shiozuka, Takashi Momoi, Ichiro Kimura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the effect of activin A on the in vitro differentiation of primary myogenic cells isolated from chick embryonic breast muscle. As judged by the morphology of the cells and accumulation of creatine kinase, activin A inhibited myogenesis in a dose-dependent manner. The inhibitory activity was reversibly suppressed by follistatin. Activin A also inhibited the expression of MyoD1. Our data also suggest that the inhibitory activity of activin A is exerted neither on proliferation of myoblasts or the growth of myotubes, but rather an early phase of differentiation following the withdrawal from cell cycle. A comparison of actions of activin A and TGF-β suggests that points of action is similar.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalZoological Science
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

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activins
chicks
cells
follistatin
myoblasts
muscle development
breast muscle
creatine kinase
cell cycle
dosage

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Activin A inhibits differentiation of chick myogenic cells in vitro. / Shiozuka, Masataka; Momoi, Takashi; Kimura, Ichiro.

In: Zoological Science, Vol. 14, No. 2, 01.01.1997, p. 327-330.

Research output: Contribution to journalArticle

Shiozuka, Masataka ; Momoi, Takashi ; Kimura, Ichiro. / Activin A inhibits differentiation of chick myogenic cells in vitro. In: Zoological Science. 1997 ; Vol. 14, No. 2. pp. 327-330.
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