Activin A inhibits differentiation of chick myogenic cells in vitro

Masataka Shiozuka, Takashi Momoi, Ichiro Kimura

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the effect of activin A on the in vitro differentiation of primary myogenic cells isolated from chick embryonic breast muscle. As judged by the morphology of the cells and accumulation of creatine kinase, activin A inhibited myogenesis in a dose-dependent manner. The inhibitory activity was reversibly suppressed by follistatin. Activin A also inhibited the expression of MyoD1. Our data also suggest that the inhibitory activity of activin A is exerted neither on proliferation of myoblasts or the growth of myotubes, but rather an early phase of differentiation following the withdrawal from cell cycle. A comparison of actions of activin A and TGF-β suggests that points of action is similar.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalZoological Science
Volume14
Issue number2
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

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