Activities of various enzymes of pyrimidine nucleotide and DNA synthesis in normal and neoplastic human tissues

Yoshihiko Maehara, H. Nakamura, Y. Nakane, K. Kawai, M. Okamoto, S. Nagayama, T. Shirasaka, S. Fujii

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The activities of the key enzymes by pyrimidine nucleotide and DNA syntheses in 43 human tumors and 28 normal human tissues were investigated. The activities of cytidine triphosphate synthetase, deoxycytidine monophosphate deaminase, uridine kinase, thymidine monophosphate kinase and DNA polymerase were markedly increased in tumor tissues, compared with those in the corresponding normal tissues, while the activities of deoxycytidine kinase, cytidine deaminase and deoxycytidine deaminase were only slightly increased. The use of thymidine and deoxyuridine as substrates of human pyrimidine nucleoside phosphorylase gave 1 to 2 orders of magnitude higher activity than that of uridine.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalGann, The Japanese Journal of Cancer Research
Volume73
Issue number2
Publication statusPublished - Sep 10 1982

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Maehara, Y., Nakamura, H., Nakane, Y., Kawai, K., Okamoto, M., Nagayama, S., ... Fujii, S. (1982). Activities of various enzymes of pyrimidine nucleotide and DNA synthesis in normal and neoplastic human tissues. Gann, The Japanese Journal of Cancer Research, 73(2), 289-298.