Acute ‘bilineal‐biphenotypic’ leukaemia

Koichi Akashi; Tsunefumi Shibuya; Mine Harada; Eiji Morioka; Koichi Oshima; Nobuhiro Kimura; Morishige Takeshita; Mamoru Kurokawa; Masahiro Kikuchi; Yoshiyuki Niho

doi:10.1111/j.1365-2141.1990.tb06326.x

Acute ‘bilineal‐biphenotypic’ leukaemia

Koichi Akashi, Tsunefumi Shibuya, Mine Harada, Eiji Morioka, Koichi Oshima, Nobuhiro Kimura, Morishige Takeshita, Mamoru Kurokawa, Masahiro Kikuchi, Yoshiyuki Niho

Kyushu University Hospital

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.

Original language	English
Pages (from-to)	402-407
Number of pages	6
Journal	British Journal of Haematology
Volume	74
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-2141.1990.tb06326.x
Publication status	Published - Apr 1990

All Science Journal Classification (ASJC) codes

Hematology

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10.1111/j.1365-2141.1990.tb06326.x

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title = "Acute {\textquoteleft}bilineal‐biphenotypic{\textquoteright} leukaemia",

abstract = "We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.",

author = "Koichi Akashi and Tsunefumi Shibuya and Mine Harada and Eiji Morioka and Koichi Oshima and Nobuhiro Kimura and Morishige Takeshita and Mamoru Kurokawa and Masahiro Kikuchi and Yoshiyuki Niho",

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AU - Akashi, Koichi

AU - Shibuya, Tsunefumi

AU - Harada, Mine

AU - Morioka, Eiji

AU - Oshima, Koichi

AU - Kimura, Nobuhiro

AU - Takeshita, Morishige

AU - Kurokawa, Mamoru

AU - Kikuchi, Masahiro

AU - Niho, Yoshiyuki

PY - 1990/4

Y1 - 1990/4

N2 - We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.

AB - We describe a unique case of hybrid leukaemia with bilineal and biphenotypic features. The coexistence of lymphoblasts and monoblasts was determined morphologically and cytochemically. Immunofluorescence and immunohistochemical analysis revealed that each blast population had both T lymphoid (CD2, cytoplasmic CD3) and myeloid (CD11, CD13, CD15) markers. Southern blot analysis of DNA extracted from the lymph node biopsy demonstrated the presence of monoclonal rearrangement of the TcR‐Cβ gene. Cytogenetic analysis of the bone marrow cells showed a karyotype of 48, XY, 7q + in all of the metaphases examined. These observations are suggestive of a monoclonal origin for these two distinct blast populations.

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Acute ‘bilineal‐biphenotypic’ leukaemia

Abstract

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