Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy.

Ryoko Nagaishi, Yuko Akehi, Kenji Ashida, Kazuna Higuchi-Tubouchi, Hiroshi Yokoyama, Takeshi Nojiri, Mikiko Aoki, Keizo Anzai, Kazuki Nabeshima, Masatoshi Tanaka, Junko Ono, Toshihiko Yanase

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Abstract

We herein describe the case of a 30-year-old woman who experienced high fever during the puerperal period and was diagnosed with pheochromocytoma. Acute inflammatory syndrome, as indicated by the elevated serum levels of interleukin-6 (IL-6), and cholestatic liver dysfunction were observed. Since this condition resolved before the operation, it was probably caused by massive central necrosis within the tumor. The IL-6 production from the tumor cells was confirmed by immunohistochemistry. When a case of pheochromocytoma accompanied with acute inflammatory syndrome is encountered, the possibility that the tumor itself might produce some cytokines should be considered, even in the presence of massive necrosis within the tumor.

Original languageEnglish
Pages (from-to)10-18
Number of pages9
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume101
Issue number1
Publication statusPublished - Jan 1 2010

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Intrahepatic Cholestasis
Pheochromocytoma
Interleukin-6
Pregnancy
Neoplasms
Necrosis
Liver Diseases
Fever
Immunohistochemistry
Cytokines
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Nagaishi, R., Akehi, Y., Ashida, K., Higuchi-Tubouchi, K., Yokoyama, H., Nojiri, T., ... Yanase, T. (2010). Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy. Fukuoka igaku zasshi = Hukuoka acta medica, 101(1), 10-18.

Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy. / Nagaishi, Ryoko; Akehi, Yuko; Ashida, Kenji; Higuchi-Tubouchi, Kazuna; Yokoyama, Hiroshi; Nojiri, Takeshi; Aoki, Mikiko; Anzai, Keizo; Nabeshima, Kazuki; Tanaka, Masatoshi; Ono, Junko; Yanase, Toshihiko.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 101, No. 1, 01.01.2010, p. 10-18.

Research output: Contribution to journalArticle

Nagaishi, R, Akehi, Y, Ashida, K, Higuchi-Tubouchi, K, Yokoyama, H, Nojiri, T, Aoki, M, Anzai, K, Nabeshima, K, Tanaka, M, Ono, J & Yanase, T 2010, 'Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy.', Fukuoka igaku zasshi = Hukuoka acta medica, vol. 101, no. 1, pp. 10-18.
Nagaishi, Ryoko ; Akehi, Yuko ; Ashida, Kenji ; Higuchi-Tubouchi, Kazuna ; Yokoyama, Hiroshi ; Nojiri, Takeshi ; Aoki, Mikiko ; Anzai, Keizo ; Nabeshima, Kazuki ; Tanaka, Masatoshi ; Ono, Junko ; Yanase, Toshihiko. / Acute inflammatory syndrome and intrahepatic cholestasis caused by an interleukin-6-producing pheochromocytoma with pregnancy. In: Fukuoka igaku zasshi = Hukuoka acta medica. 2010 ; Vol. 101, No. 1. pp. 10-18.
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