Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts

Luke F. Peterson; Anita Boyapati; Eun Young Ahn; Joseph R. Biggs; Joo Okumura Akiko; Miao Chia Lo; Ming Yan; Dong Er Zhang

doi:10.1182/blood-2006-11-019265

Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts

Luke F. Peterson, Anita Boyapati, Eun Young Ahn, Joseph R. Biggs, Joo Okumura Akiko, Miao Chia Lo, Ming Yan, Dong Er Zhang

Research output: Contribution to journal › Review article › peer-review

98 Citations (Scopus)

Abstract

Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

Original language	English
Pages (from-to)	799-805
Number of pages	7
Journal	Blood
Volume	110
Issue number	3
DOIs	https://doi.org/10.1182/blood-2006-11-019265
Publication status	Published - Aug 1 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Immunology
Hematology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1182/blood-2006-11-019265

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title = "Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts",

abstract = "Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.",

author = "Peterson, {Luke F.} and Anita Boyapati and Ahn, {Eun Young} and Biggs, {Joseph R.} and Akiko, {Joo Okumura} and Lo, {Miao Chia} and Ming Yan and Zhang, {Dong Er}",

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T1 - Acute myeloid leukemia with the 8q22;21q22 translocation

T2 - Secondary mutational events and alternative t(8;21) transcripts

AU - Peterson, Luke F.

AU - Boyapati, Anita

AU - Ahn, Eun Young

AU - Biggs, Joseph R.

AU - Akiko, Joo Okumura

AU - Lo, Miao Chia

AU - Yan, Ming

AU - Zhang, Dong Er

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

AB - Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

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Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts

Abstract

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