Acute myeloid leukemia with the 8q22;21q22 translocation: Secondary mutational events and alternative t(8;21) transcripts

Luke F. Peterson, Anita Boyapati, Eun Young Ahn, Joseph R. Biggs, Joo Okumura Akiko, Miao Chia Lo, Ming Yan, Dong Er Zhang

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

Nonrandom and somatically acquired chromosomal translocations can be identified in nearly 50% of human acute myeloid leukemias. One common chromosomal translocation in this disease is the 8q22;21q22 translocation. It involves the AML1 (RUNX1) gene on chromosome 21 and the ETO (MTG8, RUNX1T1) gene on chromosome 8 generating the AML1-ETO fusion proteins. In this review, we survey recent advances made involving secondary mutational events and alternative t(8;21) transcripts in relation to understanding AML1-ETO leukemogenesis.

Original languageEnglish
Pages (from-to)799-805
Number of pages7
JournalBlood
Volume110
Issue number3
DOIs
Publication statusPublished - Aug 1 2007
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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