Acute-phase proteins and chlamydia pneumoniae infection: Which one is more important in acute coronary syndrome?

H. Song, H. Tasaki, A. Yashiro, K. Yamashita, Hatsumi Taniguchi, Y. Nakashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Elevated levels of acute-phase proteins, a systemic marker for inflammation, predict coronary events; Chlamydia pneumoniae (C. pneumoniae) infection is associated with coronary atherosclerosis. The present study investigated whether inflammation or infection is involved in the pathogenesis of acute coronary syndrome (ACS) and which one has the more important role. The study group comprised 49 patients with angiographically diagnosed ACS, 48 cases of chronic coronary heart disease (CCHD), and 44 subjects with a normal coronary profile. The levels of serum C-reactive protein (CRP), fibrinogen and anti-C. pneumoniae IgG antibody were measured. The IgG antibody against C. pneumoniae was higher in the ACS and CCHD groups compared with the control group after adjusting for age and gender. The levels of CRP and fibrinogen were significantly increased in patients with ACS compared with controls and CCHD patients. Multiple stepwise logistic regression analysis revealed that C. pneumoniae IgG antibody is an independent risk factor for both ACS and CCHD (odds ratio 2.3 and 2.1, respectively), but the CRP level is a risk factor only for ACS (odds ratio 6.9). The inflammatory response, as indicated by acute-phase proteins, especially CRP, rather than C. pneumoniae infection, may contribute more to the clinical course of ACS.

Original languageEnglish
Pages (from-to)853-857
Number of pages5
JournalJAPANESE CIRCULATION JOURNAL
Volume65
Issue number10
DOIs
Publication statusPublished - Nov 17 2001
Externally publishedYes

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Chlamydophila pneumoniae
Chlamydia Infections
Acute-Phase Proteins
Acute Coronary Syndrome
C-Reactive Protein
Coronary Disease
Immunoglobulin G
Fibrinogen
Antibodies
Odds Ratio
Inflammation
Protein C
Blood Proteins
Coronary Artery Disease
Logistic Models
Regression Analysis
Control Groups
Infection

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Acute-phase proteins and chlamydia pneumoniae infection : Which one is more important in acute coronary syndrome? / Song, H.; Tasaki, H.; Yashiro, A.; Yamashita, K.; Taniguchi, Hatsumi; Nakashima, Y.

In: JAPANESE CIRCULATION JOURNAL, Vol. 65, No. 10, 17.11.2001, p. 853-857.

Research output: Contribution to journalArticle

Song, H. ; Tasaki, H. ; Yashiro, A. ; Yamashita, K. ; Taniguchi, Hatsumi ; Nakashima, Y. / Acute-phase proteins and chlamydia pneumoniae infection : Which one is more important in acute coronary syndrome?. In: JAPANESE CIRCULATION JOURNAL. 2001 ; Vol. 65, No. 10. pp. 853-857.
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