Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

Gotaro Shirakami, Kazuwa Nakao, Yoshihiko Saito, Tatsuo Magaribuchi, Michihisa Jougasaki, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Shin ichi Suga, Yoshihiro Ogawa, Takayuki Yamada, Kenjiro Mori, Hiroo Imura

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126 Citations (Scopus)

Abstract

To investigate the effect of pulmonary alveolar hypoxia on the sunthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10 % O2 or 5 % O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.

Original languageEnglish
Pages (from-to)969-976
Number of pages8
JournalLife Sciences
Volume48
Issue number10
DOIs
Publication statusPublished - 1991
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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