Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

Gotaro Shirakami; Kazuwa Nakao; Yoshihiko Saito; Tatsuo Magaribuchi; Michihisa Jougasaki; Masashi Mukoyama; Hiroshi Arai; Kiminori Hosoda; Shin ichi Suga; Yoshihiro Ogawa; Takayuki Yamada; Kenjiro Mori; Hiroo Imura

doi:10.1016/0024-3205(91)90362-F

Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

Gotaro Shirakami, Kazuwa Nakao, Yoshihiko Saito, Tatsuo Magaribuchi, Michihisa Jougasaki, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Shin ichi Suga, Yoshihiro Ogawa, Takayuki Yamada, Kenjiro Mori, Hiroo Imura

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To investigate the effect of pulmonary alveolar hypoxia on the sunthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10 % O₂ or 5 % O₂) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.

Original language	English
Pages (from-to)	969-976
Number of pages	8
Journal	Life Sciences
Volume	48
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(91)90362-F
Publication status	Published - 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

Access to Document

10.1016/0024-3205(91)90362-F

Cite this

@article{c930faecc27e49e9ba7f06268e28eb12,

title = "Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats",

abstract = "To investigate the effect of pulmonary alveolar hypoxia on the sunthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10 % O2 or 5 % O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.",

author = "Gotaro Shirakami and Kazuwa Nakao and Yoshihiko Saito and Tatsuo Magaribuchi and Michihisa Jougasaki and Masashi Mukoyama and Hiroshi Arai and Kiminori Hosoda and Suga, {Shin ichi} and Yoshihiro Ogawa and Takayuki Yamada and Kenjiro Mori and Hiroo Imura",

year = "1991",

doi = "10.1016/0024-3205(91)90362-F",

language = "English",

volume = "48",

pages = "969--976",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "10",

}

TY - JOUR

T1 - Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

AU - Shirakami, Gotaro

AU - Nakao, Kazuwa

AU - Saito, Yoshihiko

AU - Magaribuchi, Tatsuo

AU - Jougasaki, Michihisa

AU - Mukoyama, Masashi

AU - Arai, Hiroshi

AU - Hosoda, Kiminori

AU - Suga, Shin ichi

AU - Ogawa, Yoshihiro

AU - Yamada, Takayuki

AU - Mori, Kenjiro

AU - Imura, Hiroo

PY - 1991

Y1 - 1991

N2 - To investigate the effect of pulmonary alveolar hypoxia on the sunthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10 % O2 or 5 % O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.

AB - To investigate the effect of pulmonary alveolar hypoxia on the sunthesis and release of endothelin (ET)-1, ET-1-like immunoreactivity (-LI) levels of the lung and plasma were measured in conscious unrestrained rats under hypoxic conditions. Sixty-min exposure to alveolar hypoxia (10 % O2 or 5 % O2) increased the ET-1-LI level in the lung. The plasma ET-1-LI level in hypoxic rats also increased significantly. The increase of plasma and lung ET-1-LI levels were parallel to the severity of hypoxia. These results demonstrates that acute pulmonary alveolar hypoxia increases lung and plasma ET-1-LI levels in conscious unrestrained rats, suggesting a possible physiological or pathophysiological significance of ET in alveolar hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=0026081891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026081891&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(91)90362-F

DO - 10.1016/0024-3205(91)90362-F

M3 - Article

C2 - 1825687

AN - SCOPUS:0026081891

SN - 0024-3205

VL - 48

SP - 969

EP - 976

JO - Life Sciences

JF - Life Sciences

IS - 10

ER -

Acute pulmonary alveolar hypoxia increases lung and plasma endothelin-1 levels in conscious rats

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this