Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats

Masao Yamasaki, Keiko Mansho, Yuuya Ogino, Masaaki Kasai, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

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Abstract

The purpose of this study was to clarify the effect of conjugated linoleic acid on lipid accumulation in adipose tissue. Sprague-Dawley rats were fed a diet containing 2% conjugated linoleic acid for 1, 3, 6, and 12 weeks. In rats fed 2% conjugated linoleic acid, the weight of perirenal white adipose tissue was comparable with that of rats fed a conjugated linoleic acid-free diet. For fatty acid composition of perirenal white adipose tissue, both 16:1/16:0 and 18:1/18:0 ratios were significantly lower in the conjugated linoleic acid-fed group than the control group. Although there was no remarkable difference in serum triglyceride, total cholesterol, and phospholipid levels between dietary groups, serum leptin level was significantly lower than the control group, and lipid content in the perirenal white adipose tissue exerted a tendency toward low compared to the control value at 1-week feeding. On the other hand, leptin level in perirenal white adipose tissue was significantly lower in the conjugated linoleic acid-fed group than the control group at 12-week feeding. In conclusion, these observations suggest dietary conjugated linoleic acid is an acute reducer of serum leptin level. This may afford an explanation of the mechanism of anti-obesity effect in conjugated linoleic acid. (C) Elsevier Science Inc. 2000.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalJournal of Nutritional Biochemistry
Volume11
Issue number9
DOIs
Publication statusPublished - Dec 4 2000

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Conjugated Linoleic Acids
Leptin
Sprague Dawley Rats
Rats
White Adipose Tissue
Serum
Tissue
Nutrition
Control Groups
Diet
Lipids
Adipose Tissue
Phospholipids
Triglycerides
Fatty Acids
Obesity
Cholesterol
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats. / Yamasaki, Masao; Mansho, Keiko; Ogino, Yuuya; Kasai, Masaaki; Tachibana, Hirofumi; Yamada, Koji.

In: Journal of Nutritional Biochemistry, Vol. 11, No. 9, 04.12.2000, p. 467-471.

Research output: Contribution to journalArticle

Yamasaki, Masao ; Mansho, Keiko ; Ogino, Yuuya ; Kasai, Masaaki ; Tachibana, Hirofumi ; Yamada, Koji. / Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats. In: Journal of Nutritional Biochemistry. 2000 ; Vol. 11, No. 9. pp. 467-471.
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