Abstract
Purpose: To examine the factors associated with anatomic and visual outcomes in Japanese patients with acute retinal necrosis (ARN). Methods: One hundred four patients with ARN who were followed for more than 1 year at nine referral centers were reviewed. Retinal involvement at initial presentation was classified into four groups: zone 1 (posterior pole, n = 22), zone 2 (midperiphery, n = 54), zone 3 (periphery, n = 25), and unknown (n = 3). Forty-eight eyes underwent prophylactic vitrectomy before development of retinal detachment (vitrectomy group); 56 eyes were treated conventionally without prophylactic vitrectomy (observation group). Results: The retina was attached in 28 of 48 eyes (58.3 %) in the vitrectomy group and 42 of 56 eyes (75.0 %) in the observation group at the final visit (P = 0.071). At 1 year, 56 eyes (53.8 %) had a best-corrected visual acuity (BCVA) of 20/200 or worse. Multivariate logistic regression analyses identified zone 1 disease (odds ratio = 4.983) and optic nerve involvement (odds ratio = 5.084) as significantly associated with BCVA of 20/200 or worse. Among the zone 3 eyes, significantly (P = 0.012) more eyes in the observation group than in the vitrectomy group had an attached retina. Conclusions: Prophylactic vitrectomy did not improve the final BCVA in any eyes. Zone 3 eyes had better outcomes without prophylactic vitrectomy.
| Original language | English |
|---|---|
| Pages (from-to) | 98-103 |
| Number of pages | 6 |
| Journal | Japanese Journal of Ophthalmology |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2013 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Acute retinal necrosis : Factors associated with anatomic and visual outcomes. / Iwahashi-Shima, Chiharu; Azumi, Atsushi; Ohguro, Nobuyuki; Okada, Annabelle A.; Kaburaki, Toshikatsu; Goto, Hiroshi; Sonoda, Kohei; Namba, Kenichi; Mizuki, Nobuhisa; Mochizuki, Manabu.
In: Japanese Journal of Ophthalmology, Vol. 57, No. 1, 01.01.2013, p. 98-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute retinal necrosis
T2 - Factors associated with anatomic and visual outcomes
AU - Iwahashi-Shima, Chiharu
AU - Azumi, Atsushi
AU - Ohguro, Nobuyuki
AU - Okada, Annabelle A.
AU - Kaburaki, Toshikatsu
AU - Goto, Hiroshi
AU - Sonoda, Kohei
AU - Namba, Kenichi
AU - Mizuki, Nobuhisa
AU - Mochizuki, Manabu
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Purpose: To examine the factors associated with anatomic and visual outcomes in Japanese patients with acute retinal necrosis (ARN). Methods: One hundred four patients with ARN who were followed for more than 1 year at nine referral centers were reviewed. Retinal involvement at initial presentation was classified into four groups: zone 1 (posterior pole, n = 22), zone 2 (midperiphery, n = 54), zone 3 (periphery, n = 25), and unknown (n = 3). Forty-eight eyes underwent prophylactic vitrectomy before development of retinal detachment (vitrectomy group); 56 eyes were treated conventionally without prophylactic vitrectomy (observation group). Results: The retina was attached in 28 of 48 eyes (58.3 %) in the vitrectomy group and 42 of 56 eyes (75.0 %) in the observation group at the final visit (P = 0.071). At 1 year, 56 eyes (53.8 %) had a best-corrected visual acuity (BCVA) of 20/200 or worse. Multivariate logistic regression analyses identified zone 1 disease (odds ratio = 4.983) and optic nerve involvement (odds ratio = 5.084) as significantly associated with BCVA of 20/200 or worse. Among the zone 3 eyes, significantly (P = 0.012) more eyes in the observation group than in the vitrectomy group had an attached retina. Conclusions: Prophylactic vitrectomy did not improve the final BCVA in any eyes. Zone 3 eyes had better outcomes without prophylactic vitrectomy.
AB - Purpose: To examine the factors associated with anatomic and visual outcomes in Japanese patients with acute retinal necrosis (ARN). Methods: One hundred four patients with ARN who were followed for more than 1 year at nine referral centers were reviewed. Retinal involvement at initial presentation was classified into four groups: zone 1 (posterior pole, n = 22), zone 2 (midperiphery, n = 54), zone 3 (periphery, n = 25), and unknown (n = 3). Forty-eight eyes underwent prophylactic vitrectomy before development of retinal detachment (vitrectomy group); 56 eyes were treated conventionally without prophylactic vitrectomy (observation group). Results: The retina was attached in 28 of 48 eyes (58.3 %) in the vitrectomy group and 42 of 56 eyes (75.0 %) in the observation group at the final visit (P = 0.071). At 1 year, 56 eyes (53.8 %) had a best-corrected visual acuity (BCVA) of 20/200 or worse. Multivariate logistic regression analyses identified zone 1 disease (odds ratio = 4.983) and optic nerve involvement (odds ratio = 5.084) as significantly associated with BCVA of 20/200 or worse. Among the zone 3 eyes, significantly (P = 0.012) more eyes in the observation group than in the vitrectomy group had an attached retina. Conclusions: Prophylactic vitrectomy did not improve the final BCVA in any eyes. Zone 3 eyes had better outcomes without prophylactic vitrectomy.
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U2 - 10.1007/s10384-012-0211-y
DO - 10.1007/s10384-012-0211-y
M3 - Article
C2 - 23117419
AN - SCOPUS:84872611057
VL - 57
SP - 98
EP - 103
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
SN - 0021-5155
IS - 1
ER -