Acute retinal necrosis: Factors associated with anatomic and visual outcomes

Chiharu Iwahashi-Shima, Atsushi Azumi, Nobuyuki Ohguro, Annabelle A. Okada, Toshikatsu Kaburaki, Hiroshi Goto, Koh Hei Sonoda, Kenichi Namba, Nobuhisa Mizuki, Manabu Mochizuki

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Abstract

Purpose: To examine the factors associated with anatomic and visual outcomes in Japanese patients with acute retinal necrosis (ARN). Methods: One hundred four patients with ARN who were followed for more than 1 year at nine referral centers were reviewed. Retinal involvement at initial presentation was classified into four groups: zone 1 (posterior pole, n = 22), zone 2 (midperiphery, n = 54), zone 3 (periphery, n = 25), and unknown (n = 3). Forty-eight eyes underwent prophylactic vitrectomy before development of retinal detachment (vitrectomy group); 56 eyes were treated conventionally without prophylactic vitrectomy (observation group). Results: The retina was attached in 28 of 48 eyes (58.3 %) in the vitrectomy group and 42 of 56 eyes (75.0 %) in the observation group at the final visit (P = 0.071). At 1 year, 56 eyes (53.8 %) had a best-corrected visual acuity (BCVA) of 20/200 or worse. Multivariate logistic regression analyses identified zone 1 disease (odds ratio = 4.983) and optic nerve involvement (odds ratio = 5.084) as significantly associated with BCVA of 20/200 or worse. Among the zone 3 eyes, significantly (P = 0.012) more eyes in the observation group than in the vitrectomy group had an attached retina. Conclusions: Prophylactic vitrectomy did not improve the final BCVA in any eyes. Zone 3 eyes had better outcomes without prophylactic vitrectomy.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalJapanese Journal of Ophthalmology
Volume57
Issue number1
DOIs
Publication statusPublished - Jan 2013

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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    Iwahashi-Shima, C., Azumi, A., Ohguro, N., Okada, A. A., Kaburaki, T., Goto, H., Sonoda, K. H., Namba, K., Mizuki, N., & Mochizuki, M. (2013). Acute retinal necrosis: Factors associated with anatomic and visual outcomes. Japanese Journal of Ophthalmology, 57(1), 98-103. https://doi.org/10.1007/s10384-012-0211-y