Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy

Masafumi Nakamura, Kohei Nakata, Hideo Matsumoto, Ohtsuka Takao, Koji Yoshida, Shoji Tokunaga, Keisuke Hino

Research output: Contribution to journalArticle

Abstract

Objectives Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. Methods In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis. Results Thirteen (61.9%) of the 21 patients were diagnosed as having hypocarnitinemia after pancreatectomy. Average hepatic attenuation was as low as 42.2HU (±21.3 SD). A high ratio of acyl/free carnitine was associated with less pronounced hepatic attenuation according to both univariate (P < 0.001) and multivariate (P = 0.020) regression analyses. Conclusions The serum carnitine concentrations were low after pancreatectomy in some patients. The statistical analyses suggest that a high ratio of acyl/free carnitine is an independent risk factor for hepatic steatosis after pancreatectomy.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalPancreatology
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 1 2017

Fingerprint

Pancreatectomy
Pancreaticoduodenectomy
Carnitine
Liver
Serum
Survival Rate
Retrospective Studies
Tomography
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

Cite this

Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy. / Nakamura, Masafumi; Nakata, Kohei; Matsumoto, Hideo; Takao, Ohtsuka; Yoshida, Koji; Tokunaga, Shoji; Hino, Keisuke.

In: Pancreatology, Vol. 17, No. 1, 01.01.2017, p. 135-138.

Research output: Contribution to journalArticle

@article{8e8b15705a3542ae81cb5cfd5cf91dea,
title = "Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy",
abstract = "Objectives Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. Methods In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis. Results Thirteen (61.9{\%}) of the 21 patients were diagnosed as having hypocarnitinemia after pancreatectomy. Average hepatic attenuation was as low as 42.2HU (±21.3 SD). A high ratio of acyl/free carnitine was associated with less pronounced hepatic attenuation according to both univariate (P < 0.001) and multivariate (P = 0.020) regression analyses. Conclusions The serum carnitine concentrations were low after pancreatectomy in some patients. The statistical analyses suggest that a high ratio of acyl/free carnitine is an independent risk factor for hepatic steatosis after pancreatectomy.",
author = "Masafumi Nakamura and Kohei Nakata and Hideo Matsumoto and Ohtsuka Takao and Koji Yoshida and Shoji Tokunaga and Keisuke Hino",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.pan.2016.11.007",
language = "English",
volume = "17",
pages = "135--138",
journal = "Pancreatology",
issn = "1424-3903",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Acyl/free carnitine ratio is a risk factor for hepatic steatosis after pancreatoduodenectomy and total pancreatectomy

AU - Nakamura, Masafumi

AU - Nakata, Kohei

AU - Matsumoto, Hideo

AU - Takao, Ohtsuka

AU - Yoshida, Koji

AU - Tokunaga, Shoji

AU - Hino, Keisuke

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. Methods In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis. Results Thirteen (61.9%) of the 21 patients were diagnosed as having hypocarnitinemia after pancreatectomy. Average hepatic attenuation was as low as 42.2HU (±21.3 SD). A high ratio of acyl/free carnitine was associated with less pronounced hepatic attenuation according to both univariate (P < 0.001) and multivariate (P = 0.020) regression analyses. Conclusions The serum carnitine concentrations were low after pancreatectomy in some patients. The statistical analyses suggest that a high ratio of acyl/free carnitine is an independent risk factor for hepatic steatosis after pancreatectomy.

AB - Objectives Hepatic steatosis, one of the most frequent long-term complications of pancreatectomy, influences not only hepatic function but also survival rate. However, its risk factors and pathogenesis have not been established. The purpose of this study was to clarify the risk factors for hepatic steatosis after pancreatectomy. Methods In this retrospective study of 21 patients who had undergone pancreatectomy (19 cases of pancreatoduodenectomy and 2 cases of total pancreatectomy), serum carnitine concentrations, fractions of carnitine, and hepatic attenuation on computed tomography images were analyzed with the aim of identifying risk factors for hepatic steatosis. Results Thirteen (61.9%) of the 21 patients were diagnosed as having hypocarnitinemia after pancreatectomy. Average hepatic attenuation was as low as 42.2HU (±21.3 SD). A high ratio of acyl/free carnitine was associated with less pronounced hepatic attenuation according to both univariate (P < 0.001) and multivariate (P = 0.020) regression analyses. Conclusions The serum carnitine concentrations were low after pancreatectomy in some patients. The statistical analyses suggest that a high ratio of acyl/free carnitine is an independent risk factor for hepatic steatosis after pancreatectomy.

UR - http://www.scopus.com/inward/record.url?scp=85008156681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008156681&partnerID=8YFLogxK

U2 - 10.1016/j.pan.2016.11.007

DO - 10.1016/j.pan.2016.11.007

M3 - Article

C2 - 27939603

AN - SCOPUS:85008156681

VL - 17

SP - 135

EP - 138

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 1

ER -