Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms

Atsushi Yamashita, Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Makoto Ito, Saori Oka, Takashi Tanikawa, Keizo Waku, Takayuki Sugiura

Research output: Contribution to journalReview article

85 Citations (Scopus)

Abstract

Over one hundred different phospholipid molecular species are known to be present in mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including acyl-CoA:lysophospholipid acyltransferases, CoA-dependent and CoA-independent transacylation systems, are involved in the biosynthesis of these molecular species. Acyl-CoA:lysophospholipid acyltransferase system is involved in the synthesis of phospholipid molecular species containing sn-1 saturated and sn-2 unsaturated fatty acids. The CoA-dependent transacylation system catalyzes the transfer of fatty acids esterified in phospholipids to lysophospholipids in the presence of CoA without the generation of free fatty acids. The CoA-dependent transacylation reaction in the rat liver exhibits strict fatty acid specificity, i.e., three types of fatty acids (20:4, 18:2 and 18:0) are transferred. On the other hand, CoA-independent transacylase catalyzes the transfer of C20 and C22 polyunsaturated fatty acids from diacyl phospholipids to various lysophospholipids, especially ether-containing lysophospholipids, in the absence of any cofactors. CoA-independent transacylase is assumed to be involved in the accumulation of PUFA in ether-containing phospholipids. These enzymes are involved in not only the remodeling of fatty acids, but also the synthesis and degradation of some bioactive lipids and their precursors. In this review, recent progresses in acyltransferase research including the identification of the enzyme's genes are described.

Original languageEnglish
Pages (from-to)18-81
Number of pages64
JournalProgress in Lipid Research
Volume53
Issue number1
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Acyltransferases
Coenzyme A
Lipid Metabolism
Metabolism
Phospholipids
Lysophospholipids
Fatty Acids
Cells
Lipids
1-Acylglycerophosphocholine O-Acyltransferase
Chemical analysis
Acyl Coenzyme A
Unsaturated Fatty Acids
Phospholipid Ethers
Ether
Enzymes
Nonesterified Fatty Acids
Biosynthesis
Liver
Rats

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms. / Yamashita, Atsushi; Hayashi, Yasuhiro; Nemoto-Sasaki, Yoko; Ito, Makoto; Oka, Saori; Tanikawa, Takashi; Waku, Keizo; Sugiura, Takayuki.

In: Progress in Lipid Research, Vol. 53, No. 1, 01.01.2014, p. 18-81.

Research output: Contribution to journalReview article

Yamashita, Atsushi ; Hayashi, Yasuhiro ; Nemoto-Sasaki, Yoko ; Ito, Makoto ; Oka, Saori ; Tanikawa, Takashi ; Waku, Keizo ; Sugiura, Takayuki. / Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms. In: Progress in Lipid Research. 2014 ; Vol. 53, No. 1. pp. 18-81.
@article{feb509bf86fb44bf974db2c706baa434,
title = "Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms",
abstract = "Over one hundred different phospholipid molecular species are known to be present in mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including acyl-CoA:lysophospholipid acyltransferases, CoA-dependent and CoA-independent transacylation systems, are involved in the biosynthesis of these molecular species. Acyl-CoA:lysophospholipid acyltransferase system is involved in the synthesis of phospholipid molecular species containing sn-1 saturated and sn-2 unsaturated fatty acids. The CoA-dependent transacylation system catalyzes the transfer of fatty acids esterified in phospholipids to lysophospholipids in the presence of CoA without the generation of free fatty acids. The CoA-dependent transacylation reaction in the rat liver exhibits strict fatty acid specificity, i.e., three types of fatty acids (20:4, 18:2 and 18:0) are transferred. On the other hand, CoA-independent transacylase catalyzes the transfer of C20 and C22 polyunsaturated fatty acids from diacyl phospholipids to various lysophospholipids, especially ether-containing lysophospholipids, in the absence of any cofactors. CoA-independent transacylase is assumed to be involved in the accumulation of PUFA in ether-containing phospholipids. These enzymes are involved in not only the remodeling of fatty acids, but also the synthesis and degradation of some bioactive lipids and their precursors. In this review, recent progresses in acyltransferase research including the identification of the enzyme's genes are described.",
author = "Atsushi Yamashita and Yasuhiro Hayashi and Yoko Nemoto-Sasaki and Makoto Ito and Saori Oka and Takashi Tanikawa and Keizo Waku and Takayuki Sugiura",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.plipres.2013.10.001",
language = "English",
volume = "53",
pages = "18--81",
journal = "Progress in Lipid Research",
issn = "0163-7827",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Acyltransferases and transacylases that determine the fatty acid composition of glycerolipids and the metabolism of bioactive lipid mediators in mammalian cells and model organisms

AU - Yamashita, Atsushi

AU - Hayashi, Yasuhiro

AU - Nemoto-Sasaki, Yoko

AU - Ito, Makoto

AU - Oka, Saori

AU - Tanikawa, Takashi

AU - Waku, Keizo

AU - Sugiura, Takayuki

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Over one hundred different phospholipid molecular species are known to be present in mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including acyl-CoA:lysophospholipid acyltransferases, CoA-dependent and CoA-independent transacylation systems, are involved in the biosynthesis of these molecular species. Acyl-CoA:lysophospholipid acyltransferase system is involved in the synthesis of phospholipid molecular species containing sn-1 saturated and sn-2 unsaturated fatty acids. The CoA-dependent transacylation system catalyzes the transfer of fatty acids esterified in phospholipids to lysophospholipids in the presence of CoA without the generation of free fatty acids. The CoA-dependent transacylation reaction in the rat liver exhibits strict fatty acid specificity, i.e., three types of fatty acids (20:4, 18:2 and 18:0) are transferred. On the other hand, CoA-independent transacylase catalyzes the transfer of C20 and C22 polyunsaturated fatty acids from diacyl phospholipids to various lysophospholipids, especially ether-containing lysophospholipids, in the absence of any cofactors. CoA-independent transacylase is assumed to be involved in the accumulation of PUFA in ether-containing phospholipids. These enzymes are involved in not only the remodeling of fatty acids, but also the synthesis and degradation of some bioactive lipids and their precursors. In this review, recent progresses in acyltransferase research including the identification of the enzyme's genes are described.

AB - Over one hundred different phospholipid molecular species are known to be present in mammalian cells and tissues. Fatty acid remodeling systems for phospholipids including acyl-CoA:lysophospholipid acyltransferases, CoA-dependent and CoA-independent transacylation systems, are involved in the biosynthesis of these molecular species. Acyl-CoA:lysophospholipid acyltransferase system is involved in the synthesis of phospholipid molecular species containing sn-1 saturated and sn-2 unsaturated fatty acids. The CoA-dependent transacylation system catalyzes the transfer of fatty acids esterified in phospholipids to lysophospholipids in the presence of CoA without the generation of free fatty acids. The CoA-dependent transacylation reaction in the rat liver exhibits strict fatty acid specificity, i.e., three types of fatty acids (20:4, 18:2 and 18:0) are transferred. On the other hand, CoA-independent transacylase catalyzes the transfer of C20 and C22 polyunsaturated fatty acids from diacyl phospholipids to various lysophospholipids, especially ether-containing lysophospholipids, in the absence of any cofactors. CoA-independent transacylase is assumed to be involved in the accumulation of PUFA in ether-containing phospholipids. These enzymes are involved in not only the remodeling of fatty acids, but also the synthesis and degradation of some bioactive lipids and their precursors. In this review, recent progresses in acyltransferase research including the identification of the enzyme's genes are described.

UR - http://www.scopus.com/inward/record.url?scp=84887200411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887200411&partnerID=8YFLogxK

U2 - 10.1016/j.plipres.2013.10.001

DO - 10.1016/j.plipres.2013.10.001

M3 - Review article

C2 - 24125941

AN - SCOPUS:84887200411

VL - 53

SP - 18

EP - 81

JO - Progress in Lipid Research

JF - Progress in Lipid Research

SN - 0163-7827

IS - 1

ER -