ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children

Aya Matsusue, Chikako Kiyohara, Keiko Tanaka, Satoshi Sasaki, Yoshihiro Miyake

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: ADAM33, a disintegrin and metalloproteinase 33, gene has been identified as an asthma susceptibility gene. The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design. Methods: Seven SNPs of ADAM33 (rs2853209, rs2787094, rs2280091, rs2280090, rs628977, rs597980, and rs528557) were analyzed in 140 AD cases and 258 controls aged 3 years. Results: Only rs2853209 (T > A) was significantly associated with AD risk. Sex-adjusted odds ratio (OR) for the AA versus the TT genotype was 0.55 (95% confidence interval (CI), 0.30-0.997). Consistent with the results of genotyping analysis, a haplotype carrying rs2853209 A allele was significantly associated with decreased risk of AD compared to all the other haplotypes combined (OR = 0.26, 95% CI = 0.08-0.69). Conclusion: This is the first study to provide evidence for an association of the ADAM33 polymorphism with AD risk but the strength of this evidence is limited by our small sample size.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalClinical Biochemistry
Volume42
Issue number6
DOIs
Publication statusPublished - Apr 1 2009

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Genetic Polymorphisms
Atopic Dermatitis
Polymorphism
Haplotypes
Single Nucleotide Polymorphism
Nucleotides
Genes
Odds Ratio
Confidence Intervals
Disintegrins
Metalloproteases
Sample Size
Asthma
Alleles
Genotype

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. / Matsusue, Aya; Kiyohara, Chikako; Tanaka, Keiko; Sasaki, Satoshi; Miyake, Yoshihiro.

In: Clinical Biochemistry, Vol. 42, No. 6, 01.04.2009, p. 477-483.

Research output: Contribution to journalArticle

Matsusue, Aya ; Kiyohara, Chikako ; Tanaka, Keiko ; Sasaki, Satoshi ; Miyake, Yoshihiro. / ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children. In: Clinical Biochemistry. 2009 ; Vol. 42, No. 6. pp. 477-483.
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