ADC value and diffusion tensor imaging of prostate cancer: Changes in carbon-ion radiotherapy

Yukihisa Takayama, Riwa Kishimoto, Shouhei Hanaoka, Hiroi Nonaka, Susumu Kandatsu, Hiroshi Tsuji, Hirohiko Tsujii, Hiroo Ikehira, Takayuki Obata

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Purpose: To assess the apparent diffusion coefficient (ADC) value and diffusion tensor image (DTI) including fractional anisotropy (FA) of the noncancerous prostate and prostate cancer before and after carbon-ion radiotherapy (CIRT). Materials and Methods: Nine patients with biopsy-proven prostate cancer underwent 1.5T magnetic resonance (MR) examinations. One patient with benign prostatic hypertrophy and one healthy volunteer were also examined as references. The changes in ADC values and DTI of the entire prostate calculated from b-values of 0 and 700 (s/mm2) were estimated between before and after CIRT. Results: ADC values of prostate cancer significantly increased after CIRT by paired t-test (P < 0.01) but those of noncancerous inner gland (IG) and peripheral zone (PZ) showed no significant change. By analysis of variance, significant differences in ADC values were observed among prostate cancer and noncancerous IG and PZ before CIRT (P < 0.05). After CIRT, those significant differences had disappeared. FAs showed no significant differences in any comparisons. DTI showed changes in the direction of the main axis of the tensor in prostate cancer after CIRT. Conclusion: There were changes in ADC and DTI in prostate cancer after CIRT. They may be useful for monitoring prostatic structural changes under radiotherapy.

Original languageEnglish
Pages (from-to)1331-1335
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 1 2008

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Heavy Ion Radiotherapy
Diffusion Tensor Imaging
Prostatic Neoplasms
Prostate
Anisotropy
Prostatic Hyperplasia
Analysis of Variance
Healthy Volunteers
Magnetic Resonance Spectroscopy
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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ADC value and diffusion tensor imaging of prostate cancer : Changes in carbon-ion radiotherapy. / Takayama, Yukihisa; Kishimoto, Riwa; Hanaoka, Shouhei; Nonaka, Hiroi; Kandatsu, Susumu; Tsuji, Hiroshi; Tsujii, Hirohiko; Ikehira, Hiroo; Obata, Takayuki.

In: Journal of Magnetic Resonance Imaging, Vol. 27, No. 6, 01.06.2008, p. 1331-1335.

Research output: Contribution to journalArticle

Takayama, Y, Kishimoto, R, Hanaoka, S, Nonaka, H, Kandatsu, S, Tsuji, H, Tsujii, H, Ikehira, H & Obata, T 2008, 'ADC value and diffusion tensor imaging of prostate cancer: Changes in carbon-ion radiotherapy', Journal of Magnetic Resonance Imaging, vol. 27, no. 6, pp. 1331-1335. https://doi.org/10.1002/jmri.21388
Takayama, Yukihisa ; Kishimoto, Riwa ; Hanaoka, Shouhei ; Nonaka, Hiroi ; Kandatsu, Susumu ; Tsuji, Hiroshi ; Tsujii, Hirohiko ; Ikehira, Hiroo ; Obata, Takayuki. / ADC value and diffusion tensor imaging of prostate cancer : Changes in carbon-ion radiotherapy. In: Journal of Magnetic Resonance Imaging. 2008 ; Vol. 27, No. 6. pp. 1331-1335.
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