Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase

Hironori Kitaguchi, Kei Ohkubo, Seiji Ogo, Shunichi Fukuzumi

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

A simple additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with cumylperoxyl radical, which is expressed by the additive contributions of the reactivity of active hydrogens from the 1,4-pentadiene subunit and those of the allylic subunit; the kinetic isotope effect on the hydrogen transfer reactions (KIE = 6.1) is significantly smaller than that observed for lipoxygenase (KIE = 81).

Original languageEnglish
Pages (from-to)979-981
Number of pages3
JournalChemical Communications
Issue number9
DOIs
Publication statusPublished - Jan 1 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Additivity rule holds in the hydrogen transfer reactivity of unsaturated fatty acids with a peroxyl radical: Mechanistic insight into lipoxygenase'. Together they form a unique fingerprint.

Cite this