Adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern

Tsunehisa Kaku, Toshiharu Kamura, Toshiyuki Shigematsu, Kunihiro Sakai, Naoyuki Nakanami, Kenji Uehira, Satoshi Amada, Hiroaki Kobayashi, Toshiaki Saito, Hitoo Nakano

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Abstract

We reviewed the clinical and pathological features of seven cases of adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern. The patients, who ranged in age from 33 to 54 (mean, 45) years, underwent radical hysterectomy. In all seven cases, the tumors were papillary exophytic architecture lined by stratified epithelial cells with mild to moderate nuclear atypicality. In one of seven cases, the majority of the tumor showed villogladular papillary component, but the small foci of small cell carcinoma was present in the endocervical end of the tumor. The lymph vascular invasion was demonstrated in two of seven cases, and these two had pelvic lymph node metastases. One of these two patients had recurrence 30 months after the initial treatment and died of disease after 46 months. The follow-up ranged from 9 to 169 (median, 46) months. The presence or absence of lymph vascular invasion and minor components of this tumor such as small cell carcinoma, serous cell carcinoma, and clear cell carcinoma with a poor prognosis may be important histological findings before deciding to manage this tumor by the conservative treatment.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalGynecologic Oncology
Volume64
Issue number1
DOIs
Publication statusPublished - Jan 1 1997

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Cervix Uteri
Adenocarcinoma
Growth
Small Cell Carcinoma
Lymph
Neoplasms
Blood Vessels
Carcinoma
Hysterectomy
Lymph Nodes
Epithelial Cells
Neoplasm Metastasis
Recurrence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Kaku, T., Kamura, T., Shigematsu, T., Sakai, K., Nakanami, N., Uehira, K., ... Nakano, H. (1997). Adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern. Gynecologic Oncology, 64(1), 147-152. https://doi.org/10.1006/gyno.1996.4539

Adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern. / Kaku, Tsunehisa; Kamura, Toshiharu; Shigematsu, Toshiyuki; Sakai, Kunihiro; Nakanami, Naoyuki; Uehira, Kenji; Amada, Satoshi; Kobayashi, Hiroaki; Saito, Toshiaki; Nakano, Hitoo.

In: Gynecologic Oncology, Vol. 64, No. 1, 01.01.1997, p. 147-152.

Research output: Contribution to journalArticle

Kaku, T, Kamura, T, Shigematsu, T, Sakai, K, Nakanami, N, Uehira, K, Amada, S, Kobayashi, H, Saito, T & Nakano, H 1997, 'Adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern', Gynecologic Oncology, vol. 64, no. 1, pp. 147-152. https://doi.org/10.1006/gyno.1996.4539
Kaku, Tsunehisa ; Kamura, Toshiharu ; Shigematsu, Toshiyuki ; Sakai, Kunihiro ; Nakanami, Naoyuki ; Uehira, Kenji ; Amada, Satoshi ; Kobayashi, Hiroaki ; Saito, Toshiaki ; Nakano, Hitoo. / Adenocarcinoma of the uterine cervix with predominantly villogladular papillary growth pattern. In: Gynecologic Oncology. 1997 ; Vol. 64, No. 1. pp. 147-152.
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