Abstract
Purpose: An elemental diet (ED) can suppress inflammation in patients with Crohn’s disease (CD); however, adherence to this diet is difficult. We examined the correlation between ED adherence and the postoperative recurrence of CD. Methods: The subjects of this study were 38 patients who underwent intestinal resection with anastomosis. We defined ED adherence as consuming the average daily ED dose (≥900 kcal/day) for 2 years after surgery. Patients who did not adhere to the ED were allocated to the non-ED group. We diagnosed symptomatic recurrence using the CD activity index and endoscopic recurrence using the Rutgeerts’ score. Results: The ED and non-ED groups comprised 21 and 17 patients, respectively, with ED adherence of 55.3% (21/38). At the initial endoscopy, symptomatic and endoscopic recurrence rates were 4.8 and 14.3%, respectively, in the ED group, and 23.5 and 41.2%, respectively, in the non-ED group (P = 0.152 and P = 0.078, respectively). The overall symptomatic recurrence-free duration was significantly longer than the endoscopic recurrence-free duration (P = 0.022). Symptomatic and endoscopic recurrence-free durations were longer in the ED group than in the non-ED group (P = 0.003 and P = 0.021, respectively), and ED adherence was a prognostic factor for endoscopic recurrence (HR = 2.777, 95% CI = 1.036–8.767, P = 0.042). Conclusion: Maintaining ED adherence for 2 years after surgery improved the symptomatic and endoscopic recurrence-free durations.
| Original language | English |
|---|---|
| Pages (from-to) | 1519-1525 |
| Number of pages | 7 |
| Journal | Surgery Today |
| Volume | 47 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1 2017 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
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Adherence to an elemental diet for preventing postoperative recurrence of Crohn’s disease. / Ohara, Nobuyoshi; Mizushima, Tsunekazu; Iijima, Hideki; Takahashi, Hidekazu; Hiyama, Satoshi; Haraguchi, Naotsugu; Inoue, Takahiro; Nishimura, Junichi; Shinzaki, Shinichiro; Hata, Taishi; Matsuda, Chu; Yamamoto, Hirofumi; Doki, Yuichiro; Mori, Masaki.
In: Surgery Today, Vol. 47, No. 12, 01.12.2017, p. 1519-1525.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adherence to an elemental diet for preventing postoperative recurrence of Crohn’s disease
AU - Ohara, Nobuyoshi
AU - Mizushima, Tsunekazu
AU - Iijima, Hideki
AU - Takahashi, Hidekazu
AU - Hiyama, Satoshi
AU - Haraguchi, Naotsugu
AU - Inoue, Takahiro
AU - Nishimura, Junichi
AU - Shinzaki, Shinichiro
AU - Hata, Taishi
AU - Matsuda, Chu
AU - Yamamoto, Hirofumi
AU - Doki, Yuichiro
AU - Mori, Masaki
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Purpose: An elemental diet (ED) can suppress inflammation in patients with Crohn’s disease (CD); however, adherence to this diet is difficult. We examined the correlation between ED adherence and the postoperative recurrence of CD. Methods: The subjects of this study were 38 patients who underwent intestinal resection with anastomosis. We defined ED adherence as consuming the average daily ED dose (≥900 kcal/day) for 2 years after surgery. Patients who did not adhere to the ED were allocated to the non-ED group. We diagnosed symptomatic recurrence using the CD activity index and endoscopic recurrence using the Rutgeerts’ score. Results: The ED and non-ED groups comprised 21 and 17 patients, respectively, with ED adherence of 55.3% (21/38). At the initial endoscopy, symptomatic and endoscopic recurrence rates were 4.8 and 14.3%, respectively, in the ED group, and 23.5 and 41.2%, respectively, in the non-ED group (P = 0.152 and P = 0.078, respectively). The overall symptomatic recurrence-free duration was significantly longer than the endoscopic recurrence-free duration (P = 0.022). Symptomatic and endoscopic recurrence-free durations were longer in the ED group than in the non-ED group (P = 0.003 and P = 0.021, respectively), and ED adherence was a prognostic factor for endoscopic recurrence (HR = 2.777, 95% CI = 1.036–8.767, P = 0.042). Conclusion: Maintaining ED adherence for 2 years after surgery improved the symptomatic and endoscopic recurrence-free durations.
AB - Purpose: An elemental diet (ED) can suppress inflammation in patients with Crohn’s disease (CD); however, adherence to this diet is difficult. We examined the correlation between ED adherence and the postoperative recurrence of CD. Methods: The subjects of this study were 38 patients who underwent intestinal resection with anastomosis. We defined ED adherence as consuming the average daily ED dose (≥900 kcal/day) for 2 years after surgery. Patients who did not adhere to the ED were allocated to the non-ED group. We diagnosed symptomatic recurrence using the CD activity index and endoscopic recurrence using the Rutgeerts’ score. Results: The ED and non-ED groups comprised 21 and 17 patients, respectively, with ED adherence of 55.3% (21/38). At the initial endoscopy, symptomatic and endoscopic recurrence rates were 4.8 and 14.3%, respectively, in the ED group, and 23.5 and 41.2%, respectively, in the non-ED group (P = 0.152 and P = 0.078, respectively). The overall symptomatic recurrence-free duration was significantly longer than the endoscopic recurrence-free duration (P = 0.022). Symptomatic and endoscopic recurrence-free durations were longer in the ED group than in the non-ED group (P = 0.003 and P = 0.021, respectively), and ED adherence was a prognostic factor for endoscopic recurrence (HR = 2.777, 95% CI = 1.036–8.767, P = 0.042). Conclusion: Maintaining ED adherence for 2 years after surgery improved the symptomatic and endoscopic recurrence-free durations.
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U2 - 10.1007/s00595-017-1543-5
DO - 10.1007/s00595-017-1543-5
M3 - Article
VL - 47
SP - 1519
EP - 1525
JO - Surgery Today
JF - Surgery Today
SN - 0941-1291
IS - 12
ER -