Adhesive force between paired microdroplets coated with lipid monolayers

Miho Yanagisawa, Taka Aki Yoshida, Miyuki Furuta, Satoshi Nakata, Masayuki Tokita

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22 Citations (Scopus)

Abstract

We created pairs of adhering water-in-oil microdroplets coated with lipid monolayers as model cells and studied the effects of the physicochemical properties of the lipids on the adhesive force ΔF. Four species of liquid-phase lipids were used: dioleoylphosphatidylethanolamine (DOPE), dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), and dimyristoylphosphatidylcholine (DMPC). The dependence of ΔF on the choice of lipid was evaluated by independently measuring the interfacial tension at the oil-water interface, γ, and the contact angle between the adhering droplets. It was found that a difference in size between the hydrophilic head and hydrophobic tail of the lipids results in an increase in γ. Hence, cone-shaped DOPE had a larger γ than did cylinder-shaped PC (γ: DOPE ≫ DMPC ∼ DPPC > DOPC). On the other hand, DMPC with the shortest tail length had the smallest among the lipids (DOPC > DPPC > DOPE ≫ DMPC). Finally, it was found that ΔF drastically decreases when the carbon number of the alkyl chain in the tails is smaller than 16 (ΔF: DOPE > DOPC ∼ DPPC ≫ DMPC). Furthermore, using polyethylene glycol (PEG)-conjugated DOPE, we demonstrated that the conjugation of shorter PEG molecules (<750) to the head part of the DOPE changes its molecular shape to cylindrical, and thus its γ and ΔF become similar to those of the DOPC system.

Original languageEnglish
Pages (from-to)5891-5897
Number of pages7
JournalSoft Matter
Volume9
Issue number25
DOIs
Publication statusPublished - Jul 10 2013

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics

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  • Cite this

    Yanagisawa, M., Yoshida, T. A., Furuta, M., Nakata, S., & Tokita, M. (2013). Adhesive force between paired microdroplets coated with lipid monolayers. Soft Matter, 9(25), 5891-5897. https://doi.org/10.1039/c3sm50938a