Adipokines: Therapeutic targets for metabolic syndrome

Kunihisa Kobayashi, Toyoshi Inoguchi

    Research output: Contribution to journalReview article

    59 Citations (Scopus)

    Abstract

    For a long time it has been known that obesity (adiposity) is linked to insulin resistance. Recently, many investigators have reported that adipocytes secrete a variety of bioactive molecules, termed adipokines (adipocytokines), including TNFα, IL-6, leptin, adiponectin, resistin and so on. These adipokines play pivotal roles in energy homeostasis by affecting insulin sensitivity, glucose and lipid metabolisms, food intake, the coagulation system and inflammation. This review provides a summary of these adipose tissue-secreting biomolecules and discusses their feasibilities as drug targets for the treatment of metabolic syndrome.

    Original languageEnglish
    Pages (from-to)525-529
    Number of pages5
    JournalCurrent Drug Targets
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - Jun 1 2005

    Fingerprint

    Adipokines
    Insulin Resistance
    Insulin
    Resistin
    Adiponectin
    Adiposity
    Biomolecules
    Leptin
    Coagulation
    Lipid Metabolism
    Adipocytes
    Adipose Tissue
    Interleukin-6
    Homeostasis
    Obesity
    Eating
    Research Personnel
    Tissue
    Inflammation
    Glucose

    All Science Journal Classification (ASJC) codes

    • Molecular Medicine
    • Pharmacology
    • Drug Discovery
    • Clinical Biochemistry

    Cite this

    Adipokines : Therapeutic targets for metabolic syndrome. / Kobayashi, Kunihisa; Inoguchi, Toyoshi.

    In: Current Drug Targets, Vol. 6, No. 4, 01.06.2005, p. 525-529.

    Research output: Contribution to journalReview article

    Kobayashi, Kunihisa ; Inoguchi, Toyoshi. / Adipokines : Therapeutic targets for metabolic syndrome. In: Current Drug Targets. 2005 ; Vol. 6, No. 4. pp. 525-529.
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