Adiponectin and macrophage

Sumio Akifusa, Yoshihisa Yamashita

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adipose tissue secretes various bioactive soluble mediator called adipokines. In excess adipose tissue, increase of total amount of proinflammatory adipokines, such as TNF-α and IL-6 are observed, indicating that obesity is associated with a state of low-grade, chronic inflammation. Adiponectin, however, mature adipocyte-derived peptide, shows negative correlation with body mass index and decreases its plasma level in obese. As clinical feature, hypoadiponectinaemia is closely related with onset of metabolic syndrome, cardiovascular disease, and type II diabetes. Administration of adiponectin improves insulin resistance and/or inflammatory condition in vivo. Thus, adiponectin possessing anti-inflammatory and anti-metabolic dysfunctional characterization is expected to be used for treatment and/or preventative agent. In this review, we summarized the role of adiponectin on metabolic and immune function, in particular function of macrophage.

Original languageEnglish
Title of host publicationAdiponectin: Production, Regulation and Roles in Disease
PublisherNova Science Publishers, Inc.
Pages38-47
Number of pages10
ISBN (Print)9781619421653
Publication statusPublished - 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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