Adipose tissue inflammation and ectopic lipid accumulation

Takayoshi Suganami, Miyako Tanaka, Yoshihiro Ogawa

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Obesity may be viewed as a chronic low-grade inflammatory disease as well as a metabolic disease. Indeed, unbalanced production of pro- and anti-inflammatory adipocytokines critically contributes to the obesity-induced insulin resistance. In addition to lipid-laden mature adipocytes, adipose tissue is composed of various stromal cells such as preadipocytes, endothelial cells, fibroblasts, and immune cells that may be involved in adipose tissue functions. Accumulating evidence has suggested that adipocytes and stromal cells in adipose tissue change dramatically in number and cell type during the course of obesity, which is referred to as "adipose tissue remodeling." Among stromal cells, infiltration of macrophages in obese adipose tissue precedes the development of insulin resistance in animal models, suggesting that they are crucial for adipose tissue inflammation. We have provided evidence suggesting that a paracrine loop involving saturated fatty acids and tumor necrosis factor-α derived from adipocytes and macrophages, respectively, aggravates obesity-induced adipose tissue inflammation. On the other hand, storing excessive energy as triglyceride is also a fundamental function of adipose tissue. Recent evidence suggests that reduced lipid storage in obese adipose tissue contributes to ectopic lipid accumulation in non-adipose tissues such as the liver, skeletal muscle, and pancreas, where lipotoxicity impairs their metabolic functions. Notably, chronic inflammation is capable of inducing insulin resistance, lipolysis, and interstitial fibrosis in adipose tissue, all of which may reduce the lipid-storing function. Understanding the molecular mechanism underlying adipose tissue remodeling may lead to the identification of novel therapeutic strategies to prevent or treat obesity-induced adipose tissue inflammation.

Original languageEnglish
Pages (from-to)849-857
Number of pages9
JournalEndocrine Journal
Volume59
Issue number10
DOIs
Publication statusPublished - Nov 23 2012
Externally publishedYes

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Adipose Tissue
Inflammation
Lipids
Obesity
Stromal Cells
Adipocytes
Insulin Resistance
Macrophages
Adipokines
Lipolysis
Metabolic Diseases
Pancreas
Skeletal Muscle
Triglycerides
Fibrosis
Anti-Inflammatory Agents
Fatty Acids
Endothelial Cells
Animal Models
Tumor Necrosis Factor-alpha

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Adipose tissue inflammation and ectopic lipid accumulation. / Suganami, Takayoshi; Tanaka, Miyako; Ogawa, Yoshihiro.

In: Endocrine Journal, Vol. 59, No. 10, 23.11.2012, p. 849-857.

Research output: Contribution to journalReview article

Suganami, Takayoshi ; Tanaka, Miyako ; Ogawa, Yoshihiro. / Adipose tissue inflammation and ectopic lipid accumulation. In: Endocrine Journal. 2012 ; Vol. 59, No. 10. pp. 849-857.
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